Clinical Immunology and Immunopathology
Regular articleThe spontaneous apoptotic cell death of normal human lymphocytes in vitro: The release of, and immunoproliferative response to, nucleosomes in vitro☆
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Cited by (109)
Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis
2017, Clinical ImmunologyCitation Excerpt :In SLE, accelerated primary necrosis or accelerated apoptosis resulting in secondary necrosis, defective clearance of necrotic cells, and post-translational modifications during necrosis may play an important role in the development of LN. As previously mentioned, accelerated apoptosis leading to secondary necrosis has been observed in SLE patients and mice and promotes autoimmunity and renal damage [41,46,47,49,53–55,152,153]. Necrosis is frequently observed in subjects with LN and is associated with enhanced serological activity and proteinuria compared to LN patients that do not display necrosis [154].
Circulating Histones and Nucleosomes as Biomarkers in Sepsis and Septic Shock
2016, Epigenetic Biomarkers and DiagnosticsDifferential clearance mechanisms, neutrophil extracellular trap degradation and phagocytosis, are operative in systemic lupus erythematosus patients with distinct autoantibody specificities
2015, Immunology LettersCitation Excerpt :However, at present there is no general unifying theory that leads to the basis for this distinctive autoantibody profile. Impaired phagocytosis in SLE delays apoptotic and microbial clearance thus exposing microbial and cellular debris to the immune cells leading to autoantibody production [1–5]. In addition to delayed apoptotic and microbial clearance, an interesting and newly identified process, NETosis or neutrphil extracellular trap (NET) formation has also been implicated as an alternative source of immunogens in SLE [5].
Pullulan-histone antibody nanoconjugates for the removal of chromatin fragments from systemic circulation
2013, BiomaterialsCitation Excerpt :It has been estimated that 1011–1012 cells, primarily of haematogenous origin, die in the adult human body daily due to normal physiology, and a similar number is regenerated through mitosis to maintain homeostasis [2]. It is now well established that the chromatin fragments (Cfs) enter the systemic circulation even though most of the apoptotic bodies are cleared by the macrophages [3,4]. It is also reported that if enhanced cell death occurs due to various conditions such as autoimmune diseases, inflammatory diseases, malignant tumors, chemotherapy etc the phagocytic systems can be overloaded or impaired leading to higher levels of circulating chromosomes [4,5].
Apoptosis-regulated survival of primarily extravascular cells in proliferative active poststent neointima
2010, Cardiovascular Pathology
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Supported by a grant from the Medical Research Council of Canada.