Clinical Immunology and Immunopathology
Regular articleAutoantibodies to histones and their subfractions in chronic liver diseases
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Gastrointestinal: Liver
2011, Systemic Lupus ErythematosusNucleic acid-associated autoantigens: Pathogenic involvement and therapeutic potential
2010, Journal of AutoimmunityCitation Excerpt :In particular, H2A-H2B dimers are frequently recognized by anti-histone Abs (AHA), especially in drug-induced LE [11,13,14]. AHA can be found in a variety of diseases, including inflammatory hepatic [15], malignant, infectious [16] and, of course, rheumatic autoimmune diseases [17] (Table 1). They may be present in up to 75% of SLE sera and in more than 90% of drug-induced lupus, while their prevalence in other rheumatic diseases usually does not exceed 20% [18,19].
Gastrointestinal: Liver
2010, Systemic Lupus Erythematosus, Fifth EditionAutoantibodies in Autoimmune Liver Disease
2005, Advances in Clinical ChemistryCitation Excerpt :Antibodies to histones do not have established pathogenic effects, but their binding to the histones of the nucleosome could destabilize the nucleus and impair nuclear functions. The assay for anti‐histones is an EIA based on total histones (H1, H2A, H2B, H3, and H4) derived from calf thymus [48, 49, 227, 228]. Western blotting is required for separation of the histones and determination of the predominant individual reactivities [49].
Antihistone antibodies
2004, Systemic Lupus Erythematosus, Fourth EditionHepatic disease and systemic lupus erythematosus: Coincidence or convergence
2004, Systemic Lupus Erythematosus, Fourth Edition