Original contributionDetection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody
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2020, International Journal of Biochemistry and Cell BiologyCitation Excerpt :The chemokine MCP-1 has a complex set of immunomodulatory actions. Historically, it has been considered a pro-inflammatory mediator since it is upregulated in inflamed sites such as atherosclerotic lesions (Takeya et al., 1993) and since whole body knockout of its receptor attenuates expression of pro-inflammatory cytokines in adipose tissue (Weisberg et al., 2006). On the other hand, convincing evidence for a protective role of MCP-1 has recently emerged, specifically in terms of promoting an anti-inflammatory macrophage phenotype (Sierra-Filardi et al., 2014).
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