Original articleA quantitative assessment of pre-dental antibiotic prophylaxis for patients with mitral-valve prolapse☆
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Prophylaxis of Infective Endocarditis
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesIncidence of osteoradionecrosis in patients who have undergone dental extraction prior to radiotherapy: A systematic review and meta-analysis
2014, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :In case–control studies, prophylactic antibiotic use prevented endocarditis in <50% of cases [28–30]. Risk/benefit studies have shown that the small risk of serious reaction to antibiotics (e.g., gastrointestinal upset, hearing loss, allergy, anaphylaxis, and even death) can exceed the risk that a patient will develop endocarditis in some scenarios [31,32]. Given the controversy surrounding the use of antibiotics to prevent infection, antibiotic administration to prevent possibly non-infectious conditions, such as ORN, should be reconsidered.
Antibiotic prophylaxis to reduce the risk of joint implant contamination during dental surgery seems unnecessary
2012, Revue de Chirurgie Orthopedique et TraumatologiqueAntibiotic prophylaxis to reduce the risk of joint implant contamination during dental surgery seems unnecessary
2012, Orthopaedics and Traumatology: Surgery and ResearchCitation Excerpt :In the same study, antibiotic prophylaxis performed during tooth extraction failed to reduce OAPI risk (in hip and knee implants) [OR, 0.9; 95% CI, (0.5–1.6) versus OR, 1.2; 95% CI, (0.7–2.2) without prophylaxis]; likewise, in a subgroup with implants of less than 1 year of age, OAPI risk following dental surgery was unaffected by antibiotic prophylaxis [8]. Given its doubtful efficacy, amoxicillin or penicillin antibiotic prophylaxis should be reconsidered in terms of cost, side effects and risk of bacterium selection [61–67]. The costs of antibiotic prophylaxis are increasing with the increasing number of joint implant bearers.
Valvular Heart Disease and Heart Failure: Dental Management Considerations
2006, Dental Clinics of North AmericaCitation Excerpt :The incidence of bacteremia is as high as 88% in periodontal surgery and 100% after dental extraction [35], yet the incidence of endocarditis is low. In specific circumstances, such as prophylaxis for all cases of mitral valve prolapse, the risk of death from penicillin prophylaxis is estimated to be greater than the risk of infective endocarditis [39–41]. Nevertheless, recommendations for prophylaxis have been in place in most countries for many years, and have been periodically updated based on new scientific information.
Osteoradionecrosis prevention myths
2006, International Journal of Radiation Oncology Biology Physics
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This work was supported in part by Grant # HS04101 from the National Center for Health Services Research, OASH, and in part by the W. M. Keck Foundation Research Scholars Program of the Health Systems Management Center, Case Western Reserve University.