Rapid communcationIncrease in serum NG-hydroxy-l-arginine in rats treated with bacterial lipopolysaccharide
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Competitive ELISA method for novel estrogen-negative breast cancer biomarker quantitation
2019, Journal of Immunological MethodsDetection of HNO by Membrane Inlet Mass Spectrometry
2017, The Chemistry and Biology of Nitroxyl (HNO)Oxidation of N-hydroxy-L-arginine by hypochlorous acid to form nitroxyl (HNO)
2013, Journal of Inorganic BiochemistryCitation Excerpt :From these results, a concentration of 500 μM HOCl (and 5:1 ratio of oxidant to substrate) was selected for future experiments. Although it is unlikely that HOCl is present in vivo at this concentration, a 5:1 oxidant to substrate ratio is potentially plausible since HOCl can be generated at concentrations up to 100 μM and NOHA has been observed at concentrations of 15 μM in blood samples [25,26,41–43]. MIMS experiments following the addition of 500 μM HOCl to a PBS solution containing 100 μM NOHA reveal a rise in both the m/z 30 and 44 signals (Fig. 3).
Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease
2010, Pharmacology and TherapeuticsCitation Excerpt :The complex regulation between NOSs and arginases activity is underlined by the fact that Nω-hydroxy-l-arginine, the intermediate of NOS catalysis, represents a potent physiological inhibitor of arginase (Ki = 10 µM) (Christianson, 2005). It can be liberated from the active site of NOSs and circulate in blood in concentrations up to ∼9 µM (Hecker et al., 1995; Meyer et al., 1997). These concentrations appear to be sufficient to affect arginase activity under physiological conditions.
N-Hydroxyguanidines oxidation by a N<inf>3</inf>S copper-complex mimicking the reactivity of Dopamine β-Hydroxylase
2009, Journal of Inorganic BiochemistryOxidative and Nitrosative Stress and Fibrogenic Response
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