The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors

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Abstract

Native γ-trace, a small basic protein present in high concentration in cerebrospinal fluid, semen and neuroendocrine cells, but of unknown biological function, is shown to be a potent inhibitor of the cysteine proteinases papain, ficin, and human cathepsins B, H and L. It proves to be the tightest-binding protein inhibitor of cathepsin B so far discovered. The name cystatin C is proposed for γ-trace to reflect the many similarities in activity and structure to chicken egg-white cystatin and mammalian cystatins A and B. The inhibition constants of cystatin C, taken together with its widespread distribution in human tissues and extracellular fluids, suggest that a physiological function could well be the regulation of cysteine proteinase activity.

References (32)

  • J. Brzin et al.

    Biochem. Biophys. Res. Commun

    (1984)
  • C. Tonnelle et al.

    Biochem. Biophys. Res. Commun

    (1979)
  • D.R. Hathaway et al.

    J. Biol. Chem

    (1982)
  • A.J. Barrett

    Biochim. Biophys. Acta

    (1974)
  • A.J. Barrett

    Methods Enzymol

    (1981)
  • K. Takio et al.

    Biochem. Biophys. Res. Commun

    (1983)
  • D. Iwata et al.

    Biochem. Biophys. Res. Commun

    (1982)
  • M. Hirado et al.

    Biochim. Biophys. Acta

    (1983)
  • J.F. Lenney et al.

    Biochem. Biophys. Res. Commun

    (1982)
  • F. Gauthier et al.

    Biochem. Biophys. Res. Commun

    (1983)
  • M. Ja̋rvinen et al.

    Biochim. Biophys. Acta

    (1982)
  • J. Clausen
  • C.F.C. MacPherson et al.

    Can. J. Biochem

    (1961)
  • E.A. Butler et al.

    J. Clin. Pathol

    (1961)
  • H. Lőfberg et al.

    Acta Endocrinol. (Copenh.)

    (1982)
  • H. Lőfberg et al.

    Biomed. Res

    (1981)
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