Prognostic importance of cardiac arrhythmias in systemic sclerosis☆
References (45)
- et al.
Pathologic observations in systemic sclerosis (scleroderma): a study of fifty-eight autopsy cases and fifty-eight matched controls
Am J Med
(1969) - et al.
The heart in scleroderma
Am J Cardiol
(1966) - et al.
Prediction of survival in progressive systemic sclerosis by multivariate analysis of clinical features
Am Heart J
(1985) Progressive systemic sclerosis: cardiac involvement
Clin Rheum Dis
(1979)- et al.
The electrocardiogram in systemic sclerosis (scleroderma)
- et al.
The relationship of arrhythmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis
Am J Med
(1981) Progressive systemic sclerosis
Clin Rheum Dis
(1983)- et al.
Methods and preliminary results of the Scleroderma Criteria Cooperative Study of the American Rheumatism Association
Clin Rheum Dis
(1979) - et al.
The CREST syndrome: a distinct serologic entity with anticentromere antibodies
Am J Med
(1980) - et al.
Myocardial function and perfusion of the CREST syndrome variant of progressive systemic sclerosis
Left ventricular dysfunction induced by cold exposure in patients with systemic sclerosis
Am J Med
Cardiopulmonary manifestations of systemic sclerosis
Chest
The cardiac conduction system in progressive systemic sclerosis: clinical and pathologic features of 35 patients
Am J Med
The prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction
Risk factors for sudden death after acute myocardial infarction: two-year follow-up
Am J Cardiol
Arrhythmias in patients with chronic obstructive pulmonary disease
Med Clin North Am
Pulmonary vascular changes in scleroderma
Am J Med
Prevalence and clinical correlates of pulmonary arterial hypertension in progressive systemic sclerosis
Am J Med
Pulmonary function in progressive systemic sclerosis
Survival with systemic sclerosis (scleroderma)
The cardiovascular manifestations of systemic sclerosis (scleroderma)
Curr Probl Cardiol
The prevalence of conduction defects and cardiac arrhythmias in progressive systemic sclerosis
Ann Intern Med
Cited by (136)
Sudden cardiac death, arrhythmias and abnormal electrocardiography in systemic sclerosis: A systematic review and meta-analysis
2023, Seminars in Arthritis and RheumatismCardiac involvement in systemic sclerosis: Getting to the heart of the matter
2021, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Both supraventricular and ventricular rhythm disturbances are frequently detected in 45%–61% of patients with SSc, including premature ventricular contractions, couplet and triplet beats, bigeminy, trigeminy, quadrigeminy, ventricular tachycardia, and atrial fibrillation, or flutter [32,33,35]. Different groups have reported a significant association between the presence of arrhythmias, in particular ventricular arrhythmias, with both inflammatory and fibrotic changes measured on CMR, and ventricular arrhythmias have been associated with increased mortality [33,35,36]. Autonomic dysfunction in SSc can also be detected through electrophysiological studies, with reports of higher heart rate, reduced heart rate variability, and impaired heart rate recovery in patients [37,38].
CardioRheumatology
2021, Sex Differences in Cardiac Diseases: Pathophysiology, Presentation, Diagnosis and ManagementVery early systemic sclerosis
2019, Best Practice and Research: Clinical RheumatologyDefining primary systemic sclerosis heart involvement: A scoping literature review
2019, Seminars in Arthritis and RheumatismCitation Excerpt :A number of studies reported that ventricular dysfunction was associated with the development of arrhythmias, suggesting that SSc patients with ventricular dysfunction may be at a particularly high risk of clinically significant rhythm disturbance or sudden cardiac death [5,6,234,253,275]. Independent of ventricular function, a high number of ventricular ectopic beats or premature ventricular contractions have been associated with a greater risk of sudden cardiac death [8,245,261,275]. A greater degree of SSc-associated cardiac fibrosis, detected either at biopsy or by CMR has been shown to be associated with increased risk of clinically significant arrhythmia [8,80,186].
QTc interval prolongation in Systemic Sclerosis: Correlations with clinical variables and arrhythmic risk
2017, International Journal of Cardiology
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This study was supported in part by Grants HL14985 and HL07171 from the National Institutes of Health, Bethesda, Maryland; the Scleroderma Society, Inc., New York, New York; Scleroderma Research Foundation, Columbus, New Jersey; and Janssen Pharmaceutica, Piscataway, New Jersey.