Skip to main content

Advertisement

Log in

C-Reactive Protein and Uric Acid Levels in Patients with Psoriasis

  • Brief Communication
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric acid levels should be monitored in patients with psoriasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Pepys MB, Hirschfield GM. C-reative protein: a critical update. J Clin Invest. 2003;111:1805–12.

    PubMed  CAS  Google Scholar 

  2. Paller D, Petrou I. Pediatric psoriasis: C-reactive protein levels associated with disease severity. J Invest Dermatol. 2009;102:219–27.

    Google Scholar 

  3. Strober B, Teller C, Yamauchi P, Miller JL, Hopper M, Yang YC, et al. C-reactive protein levels in psoriasis and psoriatic arthritis. Br J Dermatol. 2008;159:322–30.

    Article  PubMed  CAS  Google Scholar 

  4. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine rich foods and the risk of gout in men. N Eng J Med. 2004;350:1093–103.

    Article  CAS  Google Scholar 

  5. Brodov Y, Behar S, Goldenberg I, Boyko V, Churaqui P. Usefulness of combining serum uric acid and C-reactive protein for risk stratification of patients with coronary artery disease. Am J Cardiol. 2009;104:194–8.

    Article  PubMed  CAS  Google Scholar 

  6. Johnson AM, Rohlfs EM, Silverman LM. Proteins. In: Burtis CA, Ashwood ER, editors. Teitz fundamentals of clinical chemistry. 5th ed. Philadelphia: WB Saunders; 2001. p. 325–51.

    Google Scholar 

  7. Evans RP. Manual and automated methods for measuring urea based on modification of its reaction with diacetylmonoxime and semicarbazide. J Clin Path. 1968;21:527–9.

    Article  PubMed  CAS  Google Scholar 

  8. King EJ. Practical clinical enzymology. London: van Nostrand; 1965. p. 56–61.

  9. Vaishnavi C. C-reactive protein in bacterial infections. Immunol Infect Dis J. 1996;6:139–44.

    CAS  Google Scholar 

  10. Trivedi RC, Rebar L, Berka ES. Uric acid enzymatic method. Clin Chem. 1978;14:1908–12.

    Google Scholar 

  11. Dahi MG, Gregory MM, Scheuer PJ. Liver function tests in patients with psoriasis. Br J Med. 1971;57:625–30.

    Article  Google Scholar 

  12. Rocha PP, Santos SA, Rebelo A, Figueiredo A, Quintanilha A, Teixeira F. The inflammatory response in mild and severe psoriasis. Br J Dermatol. 2004;5:50–1.

    Google Scholar 

  13. Eroglu ES, Sade L, Yildirir A, Demir O, Bozbas H, Muderrisoglu H. Serum levels of C-reactive protein and uric acid in patients with cardiac syndrome X. Acta Cardiol. 2009;64:207–11.

    Article  PubMed  Google Scholar 

  14. Howard D, Sesso JE, Gavin J, Paul M. C-reactive protein and the risk of developing hypertension. JAMA. 2003;290:2945–51.

    Article  Google Scholar 

  15. Leczinsky TM. Inflammation and role of CRP in psoriasis. N Engl J Med. 2005;325:1672–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Harbans Lal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Isha, Jain, V.K. & Lal, H. C-Reactive Protein and Uric Acid Levels in Patients with Psoriasis. Ind J Clin Biochem 26, 309–311 (2011). https://doi.org/10.1007/s12291-011-0132-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-011-0132-4

Keywords

Navigation