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Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects

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Abstract

Personalized nutritional strategies to treat obesity may specifically influence inflammatory markers, in addition to reduce body weight. In the present study, we evaluated the effect of a hypocaloric diet based on a Mediterranean dietary pattern (MDP) on nutritional status as well as on plasma concentrations of retinol binding protein-4 (RBP4) and other proinflammatory markers. Fourty-one subjects (24F/17M; age: 37 ± 7 years; BMI: 32.2 ± 3.9 kg/m2) were assigned to follow a MDP within a caloric-restricted diet over an 8-week period. Anthropometrical, clinical, and biochemical variables were measured at baseline and endpoint after the nutritional program. Dietary intervention resulted in a mean weight loss of −4.4 ± 2.5 kg (P < 0.001) and marked reductions (P < 0.05) in plasma concentrations of RBP4, leptin, C-reactive protein, complement C3, and tumor necrosis factor-alpha (TNFα). Individuals with a higher adherence to the MDP during the nutritional intervention presented differentially higher reductions (P < 0.05) in plasma RBP4, IL6, and TNFα. In addition, the increase in the Mediterranean diet score from baseline was a significant and independent predictor factor for the decrease in plasma RBP4 concentration (P < 0.05). In conclusion, our findings suggest that following a hypocaloric diet accompanying a high adherence to a MDP resulted in specific reductions on proinflammatory markers, in addition to a significant improvement in some metabolic syndrome features induced by weight loss, which could be a good combined strategy to treat obesity as well as related metabolic and inflammatory disorders.

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Acknowledgments

We wish to thank our physician Blanca E. Martínez de Morentin, our nurse Salomé Pérez and our technician Verónica Ciaurriz, for excellent technical assistance. This work was supported by Health Department of the Government of Navarra (22/2007) and by Línea Especial about Nutrition, Obesity and Health (University of Navarra LE/97). The Capes Foundation, Ministry of Education of Brazil as well as ADA fellowships scheme of the University of Navarra also provided research grants to H. H. M. Hermsdorff (no. 375605-0) and I. Abete, respectively.

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Authors and Affiliations

  1. Department of Nutrition and Food Sciences, Physiology and Toxicology, Institute of Nutrition and Food Sciences, University of Navarra, C/Irunlarrea, 1, Pamplona, 31008, Spain

    Helen Hermana Miranda Hermsdorff, M. Ángeles Zulet, Itziar Abete & J. Alfredo Martínez

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  1. Helen Hermana Miranda Hermsdorff
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  2. M. Ángeles Zulet
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  3. Itziar Abete
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  4. J. Alfredo Martínez
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Correspondence to J. Alfredo Martínez.

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Hermsdorff, H.H.M., Zulet, M.Á., Abete, I. et al. Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects. Endocr 36, 445–451 (2009). https://doi.org/10.1007/s12020-009-9248-1

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