Abstract
Mycobacterium tuberculosis (TB) is a major cause of morbidity and mortality worldwide. Current anti-TB chemotherapies, although effective, are associated with side effects and are limited in treating drug-resistant strands. Autoimmune diseases are a leading cause of morbidity and mortality, with a growing mass of evidence implicating infections (e.g., TB) as their triggers. The burden of TB might further increase by reactivation threats hovering over millions harboring latent infection, thus, calling for novel approaches for this dire ailment. In recent years, the non-calcemic physiological actions of vitamin D have drawn a great deal of attention. In this review, we will focus on the role of vitamin D in the innate immune defense against TB on the one hand and conversely on the immunomodulatory effects of vitamin D on autoimmunity. Taken together, the suggested dual role of vitamin D in treating TB infection and possibly preventing associated autoimmunity will constitute the basis of the current review.
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References
Koch R (1882) Die aetiologie der tuberculose. Berl Klinische Wochenschr 19:221–230
Mathema B, Kurepina N, Bifani P, Kreiswirth B (2006) Molecular epidemiology of tuberculosis: current insights. Clin Microbiol Rev 19:658–685
Maartens G, Wilkinson R (2007) Tuberculosis. Lancet 370:2030–2043
WHO (2008) Global tuberculosis control: surveillance, planning, financing: WHO report. WHO, Geneva WHO/HTM/TB/2008.393
Dye C, Scheele S, Dolin P, Pathania V, Raviglione M (1999) Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country [consensus statement]. WHO Global Surveillance and Monitoring Project. JAMA 282:677–686
Comstock GW (1982) Epidemiology of tuberculosis. Am Rev Respir Dis 125:128
Iseman M, Madsen L (1989) Drug-resistant tuberculosis. Clin Chest Med 10:341–353
WHO (2008) Anti-tuberculosis drug resistance in the world: WHO Fourth Global Report. WHO, Geneva WHO/HTM/TB/2008.394
Harel M, Shoenfeld Y (2006) Predicting and preventing autoimmunity, myth or reality? Ann NY Acad Sci 1069:322–345
Shoenfeld Y, Isenberg DA (1989) The mosaic of autoimmunity. Immunol Today 10:123–126
Shoenfeld Y, Blank M, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Bizzaro N, Gilburd B, Zandman-Goddard G, Katz U, Krause I, Langevitz P, Mackay IR, Orbach H, Ram M, Sherer Y, Toubi E, Gershwin ME (2008) The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases. Isr Med Assoc J 10:13–19
Shoenfeld Y, Zandman-Goddard G, Stojanovich L, Cutolo M, Amital H, Levy Y, Abu-Shakra M, Barzilai O, Berkun Y, Blank M, de Carvalho JF, Doria A, Gilburd B, Katz U, Krause I, Langevitz P, Orbach H, Pordeus V, Ram M, Toubi E, Sherer Y (2008) The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases. Isr Med Assoc J 10:8–12
Shoenfeld Y, Gilburd B, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Blank M, Zandman-Goddard G, Katz U, Krause I, Langevitz P, Levy Y, Orbach H, Pordeus V, Ram M, Sherer Y, Toubi E, Tomer Y (2008) The mosaic of autoimmunity: genetic factors involved in autoimmune diseases. Isr Med Assoc J 10:3–7
Shoenfeld Y, Isenberg D (1988) Mycobacteria and autoimmunity. Immunol Today 9:178–182
Elkayam O, Caspi D, Lidgi M, Segal R (2007) Auto-antibody profiles in patients with active pulmonary tuberculosis. Int j Tuberc Lung Dis 11:306–310
Adams J, Hewison M (2008) Unexpected actions of vitamin-D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4:80–90
Arnson Y, Amital H, Shoenfeld Y (2007) Vitamin-D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis 66:1137–1142
Martineau A, Wilkinson R, Katalin A, Wilkinson R et al (2007) A single dose of vitamin-D enhances immunity to mycobacteria. Am J Respir Crit Care Med 176:208–213
Nursyam E, Amin Z, Rumende C (2006) The effect of vitamin-D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med Indones 38:3–5
Institute of Medicine (1997) Dietary reference intakes for calcium, magnesium, phosphorus, vitamin-D, and fluoride. National Academy, Washington, DC
Holick M (2007) Vitamin-D deficiency. N Engl J Med 357:266–281
Gibney KB, MacGregor L, Leder K et al (2008) Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis 46:443–446
Holick M, Chen T (2008) Vitamin-D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086S
Holick M (2008) Deficiency of sunlight and vitamin-D. BMJ 336:1318–1319
Zittermann A (2003) Vitamin-D in preventive medicine: are we ignoring the evidence? Br J Nutr 89:552–572
Strachan D, Powell K, Thaker A, Millard F, Maxwell J (1995) Vegetarian diet as a risk factor for tuberculosis in immigrant south London Asians. Thorax 50:175–180
Nnoaham K, Clarke A (2008) Low serum vitamin-D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol 37:113–119
Sita-Lumsden A, Lapthorn G, Swaminathan R, Milburn H (2007) Reactivation of tuberculosis and vitamin-D deficiency: the contribution of diet and exposure to sunlight. Thorax 62:1003–1007
Bellamy R, Ruwende C, Corrah T, McAdam K et al (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin-D receptor gene. J Infect Dis 179:721–724
Selvaraj P, Chandra G, Kurian S, Reetha A, Narayanan P (2003) Association of vitamin-D receptor gene variants of Bsm I, Apa I and Fok I polymorphisms with susceptibility or resistance to pulmonary tuberculosis. Curr Sci 84:1564–1568
Bornman L, Campbell S, Fielding K et al (2004) Vitamin-D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. J Infect Dis 190:1631–1641
Wilbur A, Kubatko L, Hurtado A, Hill K (2007) Stone A. Vitamin-D receptor gene polymorphisms and susceptibility M. tuberculosis in Native Paraguayans. Tuberculosis 87:329–337
Lewis S, Baker I, Davey S (2005) Meta-analysis of vitamin-D receptor polymorphisms and pulmonary tuberculosis risk. Int J Tuberc Lung Dis. 9:1174–1177
Wilkinson R, Llewelyn M, Toossi Z, Patel P et al (2000) Influence of vitamin-D deficiency and vitamin-D receptor polymorphisms on susceptibility to tuberculosis amongst Gujarati Asians in west London: a case-control study. Lancet 355:618–621
Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Narayanan P (2008) Regulatory region polymorphisms of vitamin-D receptor gene in pulmonary tuberculosis patients and normal healthy subjects of south India. Int J Immunogenetics 35:251–254
Ralph A, Kelly P, Anstey N (2008) L-arginine and vitamin-D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol 16(7):336–344
Williams CJB (1849) Cod liver oil in phthisis. London J Med 1:1–18
Charpy J (1950) Quelques traitments vitamin´es ou par substances fonctionelles en dermatologie. Bull M´ed 24:505
Martineau A, Honecker F, Wilkinson R, Griffiths C (2007) Vitamin-D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol 103:793–798
Liu P, Krutzik S, Modlin R (2007) Therapeutic implications of the TLR and VDR partnership. Trends Mol Med 13:117–124
Cosma C, Sherman D, Ramakrishnan L (2003) The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol 57:641–676
Rook G, Steele J, Fraher L et al (1986) Vitamin-D3, γ interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57:159–163
Crowle A, Ross E, May M (1987) Inhibition by 1, 25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun 55:2945–2950
Liu P, Stenger S, Wenzel H et al (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770–1773
Adams J (2006) Vitamin-D as a defensin. J Musculoskelet Neuronal Interact 6:344–346
Martineau A, Wilkinson K, Newton S et al (2007) IFN-γ- and TNF-independent vitamin-D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol 178:7190–7198
Liu P, Stenger S, Tang D, Modli R (2007) Cutting edge: Vitamin-D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 179:2060–2063
Brightbill H, Libraty D, Krutzik S et al (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285:732–736
Centers for Disease Control and Prevention (CDC) (2007) Trends in tuberculosis—United States. MMWR Morb Mortal Wkly Rep 57:281–285 2008
Ferrari G, Langen H, Naito M, Pieters J (1999) A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 97:435–447
Pieters J (2001) Evasion of host cell defense mechanisms by pathogenic bacteria. Curr Opin Immunol 13:37–44
Anand P, Kaul D (2003) Vitamin-D3-dependent pathway regulates TACO gene transcription. Biochem Biophys Res Commun 310:876–877
Anand P, Kaul D, Sharma M (2008) Synergistic action of vitamin-D and retinoic acid restricts invasion of macrophages by pathogenic mycobacteria. J Microbiol Immunol Infect 41:17–25
Watts H, Lifeso R (1996) Tuberculosis of bones and joints. J Bone Joint Surg Am 78:288–298
Hugosson C, Nyman R, Brismar J et al (1996) Imaging of tuberculosis. Peripheral osteoarticular and soft tissue tuberculosis. Acta Radiol 37:512–516
Franco-Paredes C, Díaz-Borjon A, Senger M, Barragan L, Leonard M (2006) The ever-expanding association between rheumatologic diseases and tuberculosis. Am J Med 119:470–477
Arthanari S, Yusuf S, Nisar M (2008) Tuberculosis of the knee complicating seronegative arthritis. J Rheumatol 35:1227–1228
Kakourou T, Drosatou P, Psychou F, Aroni K, Nicolaidou P (2001) Erythema nodosum in children: a prospective study. J Am Acad Dermatol. 44:17–21
Lowry K, Stephan K, Davis C (1999) Miliary tuberculosis presenting with rigors and developing unusual cutaneous manifestations. Cutis 64:23–28
Elkayam O, Segal R, Lidgi M, Caspi D (2006) Positive anti-cyclic citrullinated proteins and rheumatoid factor during active lung tuberculosis. Ann Rheum Dis 65:1110–1112
Teplizki H, Buskila D, Isenberg DA, Coates ARM, Sukenik S, Horowitz J, Shoenfeld Y (1987) Low serum anti-TB glycolipid antibodies titer in the sera of patients with SLE as an indicator of CNS involvement. J Rheumatol 14:507–511
Zandman-Goddard G, Shoenfeld Y (2005) Infections and SLE. Autoimmunity 38:473–485
Shoenfeld Y, Schwartz R (1984) Immunologic and genetic factors in autoimmune diseases. N Eng J Med 311:1019–1029
Blank M, Barzilai O, Shoenfeld Y (2007) Molecular mimicry and auto-immunity. Clin Rev Allergy Immunol 32:111–118
Doria A, Canova M, Tonon M, Zen M et al (2008) Infections as triggers and complications of systemic lupus erythematosus. Autoimmun Rev 8:24–28
Ortega-Hernandez OD, Agmon-Levin N, Blank M, Asherson RA, Shoenfeld Y (2009) The physiopathology of the catastrophic antiphospholipid (Asherson's) syndrome: compelling evidence. J Autoimmun 32:1–6
Shoenfeld Y, Vilner Y, Coates A, Rauch J, Lavie G, Shaull D, Pinkhas J (1986) Monoclonal antituberculosis antibodies react with DNA, and monoclonal anti-DNA autoantibodies react with Mycobacterium tuberculosis. Clin Exp Immunol 66:255–261
Holoshitz J, Koning F, Coligan J et al (1989) Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226–229
Holoshitz J, Klajman A, Drucker I et al (1986) T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet 2:305–309
Pope R, Wallis R, Sailer D et al (1991) T cell activation by mycobacterial antigens in inflammatory synovitis. Cell Immunol 133:95–108
Haftel H, Chang Y, Hinderer R et al (1994) Induction of the autoantigen proliferating cell nuclear antigen in T lymphocytes by a microbacterial antigen. Clin Invet 94:1365–1372
George J, Shoenfeld Y, Gilburd B, Afek A, Shaish A, Harats D (2000) Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis. Circ Res 86:1203–1210
Winfield J (1989) Stress proteins, arthritis, and autoimmunity. Arthritis Rheum 32:1497–1504
Jones D, Hunter N, Duff G (1990) Heat shock protein 65 as a β cell antigen of insulin dependent diabetes. Lancet 336:583–585
Xu Q, Willeit J, Marosi M, Kleindienst R et al (1993) Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis. Lancet 341:255–259
Perschinka H, Mayr M, Millonig G et al (2003) Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler Thromb Vasc Biol 23:1060–1065
Zhu J, Quyyumi A, Rott D et al (2001) Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis. Circulation 103:1071–1075
George J, Shoenfeld Y, Afek A, Gilburd B, Keren P, Shaish A, Kopolovic Y, Wick G, Harats D (1999) Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein 65. Arterioscler Thromb Vasc Biol 19:505–510
Harats D, Yacov N, Gilburd B, Shoenfeld Y, George J (2002) Oral tolerance with heat shock protein 65 attenuates mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic esions. JACC 40:1333–1338
Res P, Schaar C, Breedveld F et al (1988) Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis. Lancet 27:478–480
Tasneem S, Islam N, Ali R (2001) Crossreactivity of SLE autoantibodies with 70 kDa heat shock proteins of Mycobacterium tuberculosis. Microbiol Immunol 45:841–846
Salvetti M, Buttinelli C, Ristori G et al (1992) T lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kD heat shock proteins in multiple sclerosis. J Autoimmun 5:691–702
Salvetti M, Ristori G, Buttinelli C et al (1996) The immune response to mycobacterial 70 kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis. J Neuroimmunol 65:143–153
Alard J, Dueymes M, Youinou P, Jamin C (2007) Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases. Autoimmun Rev 6:438–443
Gilbertson B, Germano S, Steele P et al (2004) Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection. Infect Immun 72:6884–6891
Salgame P (2005) Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection. Curr Opin Immunol 17:374–380
Baccala R, Kono D, Theofilopoulos A (2005) Interferons as pathogenic effectors in autoimmunity. Immunol Rev 204:9–26
Gardam M, Keystone E, Menzies R et al (2003) Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. Lancet Infect Dis 3:148–155
Keane J, Gershon S, Wise R et al (2001) Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 345:1098–1104
Tincani A, Andreoli L, Bazzani C, Bosiso D, Sozzani S (2007) Inflammatory molecules: a target for treatment of systemic autoimmune diseases. Autoimmun Rev 7:1–7
Leadbetter E, Rifkin A, Hohlbaum A, Beaudette B et al (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416:603–607
Rifkin I, Leadbetter E, Busconi L, Viglianti G, Marshak-Rothstein A (2005) Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev 204:27–42
Eriksson U et al (2003) Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med 9:1484–1490
Waldner H, Collins M, Kuchroo V (2004) Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest 113:990–997
Deng G, Nilsson I, Verdrengh M et al (1999) Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 5:702–705
Segal B, Chang J, Shevach E (2000) CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J Immunol 164:5683–5688
Lang K, Recher M, Junt T et al (2005) Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 11:138–145
Nishikubo K, Imanaka-Yoshida K, Tamaki S et al (2007) Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis. J Autoimmun 29:146–153
Silver K, Crockford T, Bouriez-Jones T et al (2007) MyD88-dependent autoimmune disease in Lyn-deficient mice. Eur J Immunol 37:2734–2743
Sadanaga A, Nakashima H, Akahoshi M et al (2007) Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice. Arthritis Rheum 56:1618–1628
Mansell A, Brint E, Gould J et al (2004) Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4. J Biol Chem 279:37227–37230
Reiling N, Holscher C, Fehrenbach A et al (2002) Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169:3480–3484
Castiblanco J, Varela D, Castaño-Rodríguez N, Rojas-Villarraga A, Hincapié M, Anaya J (2008) TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol 8:541–544
Pearson C (1956) Development of arthritis, periarthritis, and periostitis in rats given adjuvant. Proc Soc Exp Biol Med 91:95–101
Holoshitz J, Matitiahu A, Cohen I (1984) Arthritis induced in rats by cloned T-lymphocytes responsive to mycobacteria but not to collagen type II. J clin Invest 73:211–215
Torisu M, Miyahara T, Shinohara N et al (1978) A new side effect of BCG immunotherapy: BCG-induced arthritis in man. Cancer Immunol Immunother 5:77–83
Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G, Danko K, Nagy E, Csepany T, Carvalho JF, Doria A, Shoenfeld Y (2007) Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin-D, and TPA levels in autoimmune diseases. Ann N Y Acad Sci 1109:385–400
Carvalho JF, Blank M, Kiss E, Tarr T, Amital H, Shoenfeld Y (2007) Anti-vitamin-D, vitamin-D in SLE: preliminary results. Ann N Y Acad Sci 1109:550–557
Cantorna M, Zhu Y, Froicu M, Wittke A (2004) Vitamin-D status, 1, 25-dihydroxyvitamin-D3, and the immune system. Am J Clin Nutr 80:1717S–1720S
Ponsonby A-L, McMichael A, van der Mei I (2002) Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology 181–182:71–78
Pappa H, Gordon C, Saslowsky T et al (2006) Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics 118:1950–1961
Nieves J, Cosman F, Herbert J, Shen V, Lindsay R (1994) High prevalence of vitamin-D deficiency and reduced bone mass in multiple sclerosis. Neurology 44:1687–1692
Aguado P, del Campo M, Garces M et al (2000) Low vitamin-D levels in outpatient postmenopausal women from a rheumatology clinic in Madrid, Spain: their relationship with bone mineral density. Osteoporos Int 11:739–744
Kamen D, Cooper G, Bouali H et al (2006) Vitamin-D deficiency in systemic lupus erythematosus. Autoimmun Rev 5:114–117
Munger K, Levin L, Hollis B, Howard N, Ascherio A (2006) Serum 25-hydroxyvitamin-D levels and risk of multiple sclerosis. JAMA 296:2832–2838
Abe J, Nakamura K, Takita Y, Nakano T, Irie H, Nishii Y (1990) Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1 alpha,25-dihydroxyvitamin-D3. J Nutr Sci Vitaminol 36:21–31
Daniel C, Radeke H, Sartory N et al (2006) The new low calcemic vitamin-D analog 22-ene-25-oxa-vitamin-D prominently ameliorates Th1-mediated colitis in mice. J Pharmacol Exp Ther 319:622–631
Cantorna M, Hayes C, DeLuca H (1996) 1, 25-Dihydroxyvitamin-D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A 93:7861–8764
Cantorna M, Humpal-Winter J, DeLuca H (1999) Dietary calcium is a major factor in 1, 25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice. J Nutr 129:1966–1971
Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R (1994) Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin-D3. Diabetologia 37:552–558
Munger K, Zhang S, O'Reilly E et al (2004) Vitamin-D intake and incidence of multiple sclerosis. Neurology 62:60–65
Merlino L, Curtis J, Mikuls T et al (2004) Vitamin-D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 50:72–77
Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B (2007) Vitamin D in rheumatoid arthritis. Autoimmun Rev 7:59–64
Goldberg P, Fleming M, Picard E (1986) Multiple sclerosis: decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin-D. Med Hypotheses 21:193–200
Birlea S, Costin G, Norris D (2008) Cellular and molecular mechanisms involved in the action of vitamin-D analogs targeting vitiligo depigmentation. Curr Drug Targets 9:345–359
Hypponen E, Laara E, Reunanen A, Jarvelin M, Virtanen S (2001) Intake of vitamin D and risk of type 1 diabetes: a birthcohort study. Lancet 358:1500–1503
Bhalla A, Amento E, Clemens T et al (1983) Specific high-affinity receptors for 1, 25-dihydroxyvitamin-D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 57:1308–1310
Provvedini D, Tsoukas C, Deftos L, Manolagas S (1986) 1 alpha, 25-Dihydroxyvitamin-D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production. J Immunol 136:2734–2740
Chen S, Sims GP, Chen X et al (2007) Modulatory effects of 1, 25-dihydroxyvitamin-D3 on human B cell differentiation. J Immunol 179:1634–1647
Doria A, Arienti S, Rampudda M, Canova M et al (2008) Preventive strategies in systemic lupus erythematosus. Autoimmun Rev 7:192–197
Overbergh L, Decallonne B, Waer M et al (2000) 1alpha, 25-dihydroxyvitamin-D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524–543). Diabetes 49:1301–1307
Bhalla A, Amento E, Serog B, Glimcher L (1984) 1, 25-Dihydroxyvitamin-D3 inhibits antigen-induced T cell activation. J Immunol 133:1748–1754
Lemire J (1992) Immunomodulatory role of 1, 25-dihydroxyvitamin-D3. J Cell Biochem 49:26–31
Lemire J, Archer D, Beck L, Spiegelberg H (1995) Immunosuppressive actions of 1, 25-dihydroxyvitamin-D3: preferential inhibition of Th1 functions. J Nutr 125:1704S–1708S
van Etten E, Mathieu C (2005) Immunoregulation by 1,25-dihydroxyvitamin-D3: basic concepts. J Steroid Biochem Mol Biol 97:93–101
Ramos-Lopez E, Jansen T, Ivaskevicius V et al (2006) Protection from type 1 diabetes by vitamin-D receptor haplotypes. Ann N Y Acad Sci 1079:327–334
Bailey R, Cooper J, Zeitels L et al (2007) Association of the vitamin-D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 56:2616–2621
Huang C, Wu M, Wu J, Tsai F (2002) Association of vitamin-D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 11:31–34
Shimada A, Kanazawa Y, Motohashi Y et al (2008) Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese. J Autoimmun 30:207–211
Penna G, Amuchastegui S, Cossetti C et al (2006) Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin-D receptor agonist elocalcitol. J Immunol 177:8504–8511
Penna G, Adorini L (2000) 1α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405–2411
Adorini L, Giarratana N, Penna G (2004) Pharmacological induction of tolerogenic dendritic cells and regulatory T cells. Semin Immunol 16:127–134
Luciano A, Giuseppe P (2008) Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4:404–412
Shoenfeld Y, Selmi C, Zimlichman E, Gershwin ME (2008) The autoimmunologist: geoepidemilogy, a new center of gravity, and prime time for autoimmunity. J Autoimmun 31:325–30
Adebajo A, Charles P, Maini R, Hazleman B (1993) Autoantibodies in malaria, tuberculosis and hepatitis B in a west African population. Clin Exp Immunol 92:73–76
Flores-Suarez LF, Cabiedes J, Villa AR, van der Woude FJ, Alcocer-Varela J (2003) Prevalence of antineutrophilic cytoplasmatic autoantibodies in patients with tuberculosis. Rheumatology 42:223–229
Sela O, el-Roeiy A, Isenberg DA, Kennedy RC, Colaco CB, Pinkhas J, Shoenfeld Y (1987) A common anti-DNA idiotype in sera of patients with active pulmonary tuberculosis. Arthritis Rheum 30:50–56
Isenberg D, Maddison P, Swana G (1987) Profile of autoantibodies in the serum of patients with tuberculosis, klebsiella and other Gram-negative infections. Clin Exp Immunol 67:516–523
Di Cesar D, Ploutz-Snyder R, Weinstock R, Moses A (2006) Vitamin D deficiency is more common in type 2 than in type 1 diabetes. Diabetes Care 29:174
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This review utilized the PubMed database; references from relevant articles; and the WHO website for identification of relevant data. Key search terms included “tuberculosis,” “vitamin D,” “vitamin D deficiency,” “autoimmune disease,” “epidemiology,” and “innate immunity.” English language papers were reviewed.
Yehuda Schoenfield is an incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases.
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Shapira, Y., Agmon-Levin, N. & Shoenfeld, Y. Mycobacterium Tuberculosis, Autoimmunity, and Vitamin D. Clinic Rev Allerg Immunol 38, 169–177 (2010). https://doi.org/10.1007/s12016-009-8150-1
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DOI: https://doi.org/10.1007/s12016-009-8150-1