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Livedo Reticularis as a Criterion for Antiphospholipid Syndrome

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Abstract

Many consensus meetings were organized in an attempt to improve the present criteria for antiphospholipid syndrome (APS) classification. In this regard, a high prevalence of antiphospholipid antibodies in systemic lupus erythematosus patients was reported in association with the presence of livedo reticularis (LR). In these studies, the association between LR, migraine, and the development of thrombosis (strokes, valvular dysfunctions) was evident. During the last decade, it was strongly suggested that many clinical symptoms (LR, valvular dysfunctions) or laboratory features (thrombocytopenia) should be considered as “minor criteria” for APS. The inclusion of these clinical symptoms in the criteria for APS classification could become of additive value especially when they exist together in one patient. This review summarizes the data that question or support this idea.

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Authors and Affiliations

  1. Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel

    E. Toubi

  2. Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

    E. Toubi

  3. Department of Internal Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, 52621, Israel

    Y. Shoenfeld

  4. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Y. Shoenfeld

  5. Laura Schwarz-Kipp Chair for Research of Autoimmunity Diseases, Tel Aviv University, Tel Aviv, Israel

    Y. Shoenfeld

Authors
  1. E. Toubi
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  2. Y. Shoenfeld
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Correspondence to Y. Shoenfeld.

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Toubi, E., Shoenfeld, Y. Livedo Reticularis as a Criterion for Antiphospholipid Syndrome. Clinic Rev Allerg Immunol 32, 138–144 (2007). https://doi.org/10.1007/s12016-007-0004-0

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  • DOI: https://doi.org/10.1007/s12016-007-0004-0

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