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Genetic Polymorphisms in the CD40 Ligand Gene and Kawasaki Disease

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Abstract

Background

Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood.

Purpose

This study aims to investigate whether polymorphisms of the CD40 ligand (CD40L) gene are associated with KD and the development of coronary artery lesions (CAL) in the Taiwanese children.

Materials and methods

The CD40L −3459 A/G and IVS4+121 A/G single nucleotide polymorphisms (SNPs) were genotyped in 167 children with KD and 1,010 ethnically matched healthy controls by TaqMan assay.

Results

None of the CD40L polymorphisms was associated with susceptibility or CAL development of KD, and this finding was supported by the haplotype analysis.

Conclusion

In summary, these results provide little support for specific CD40L SNPs in the susceptibility or CAL development of KD in Taiwanese children. However, it will be necessary to validate or replicate this association in other independent large-size ethnic groups.

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Acknowledgments

This research was supported by grant MMH E-96007 from Mackay Memorial Hospital, Taiwan.

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Authors and Affiliations

  1. Department of Pediatrics, Mackay Memorial Hospital, 45, Min-Sheng Rd., Tamshui, 25115, Taipei, Taiwan

    Fu-Yuan Huang, Ming-Ren Chen, Nan-Chang Chiu, Hsin Chi, Hung-Chang Lee, Shuan-Pei Lin & Yann-Jinn Lee

  2. Department of Medical Research, Mackay Memorial Hospital, 45, Min-Sheng Rd., Tamshui, 25115, Taipei, Taiwan

    Tzu-Yang Chang, Shuan-Pei Lin, Chih-Kai Chen, Hui-Wen Chan, Wei-Fang Chen, Hsin-Fu Liu, Chen-Chung Chu, Marie Lin & Yann-Jinn Lee

  3. Department of Pediatrics, Taipei Medical University, Taipei, Taiwan

    Fu-Yuan Huang, Hung-Chang Lee & Yann-Jinn Lee

  4. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    Ming-Ren Chen, Nan-Chang Chiu, Hsin Chi & Shuan-Pei Lin

  5. Department of Infant and Child Care, National Taipei College of Nursing, Taipei, Taiwan

    Shuan-Pei Lin

  6. Departments of Pediatrics and Medical Research, Mackay Memorial Hospital, 45, Min-Sheng Rd., Tamshui, 25115, Taipei, Taiwan

    Yann-Jinn Lee

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  1. Fu-Yuan Huang
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  2. Tzu-Yang Chang
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  7. Shuan-Pei Lin
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  10. Wei-Fang Chen
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  11. Hsin-Fu Liu
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  12. Chen-Chung Chu
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  13. Marie Lin
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Correspondence to Yann-Jinn Lee.

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Huang, FY., Chang, TY., Chen, MR. et al. Genetic Polymorphisms in the CD40 Ligand Gene and Kawasaki Disease. J Clin Immunol 28, 405–410 (2008). https://doi.org/10.1007/s10875-008-9203-6

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  • DOI: https://doi.org/10.1007/s10875-008-9203-6

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