Abstract:
To investigate the association between generalised osteoarthritis (GOA) and HLA-A, B, Cw, DQ and DR, we typed for HLA in 72 Japanese patients with GOA and compared with those of 1480 normal controls. The antigen frequency of HLA-Cw4 was significantly higher in the GOA group than in the control group. That of B62 was higher, but only uncorrected P values were significant. Those of HLA-Cw1 and Cw10 were significantly lower in the GOA group than in the control group. The antigen frequencies of HLA-DRB1*0101, *0401, *0405, *1001, and *1402, which were reported to be associated with rheumatoid arthritis, in the GOA group were not significantly different from those in the control group. The present study provides evidence of a significant association between Japanese GOA and HLA, which is different from that of Japanese RA. This may suggest that an immunological reaction that is different from RA plays a role in the pathogenesis of GOA.
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Received: 3 January 2001 / Accepted: 6 June 2001
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Wakitani, S., Imoto, K., Mazuka, T. et al. Japanese Generalised Osteoarthritis was Associated with HLA Class I – A Study of HLA-A, B, Cw, DQ, DR in 72 Patients. Clin Rheumatol 20, 417–419 (2001). https://doi.org/10.1007/s100670170006
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DOI: https://doi.org/10.1007/s100670170006