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Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol

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Abstract

Aim of this study was to develop a time-efficient sequence protocol for a 1.0 T dedicated MR system to be used for whole-organ scoring of osteoarthritis (OA). Thirty-four knees were examined using a protocol that included fat suppressed fast spin echo proton density weighted sequences (PDFS) in three planes plus a coronal STIR sequence. Two radiologists scored each knee by consensus for five OA features. In separate sessions, all knees were scored using three different combinations of sequences: (1) all four sequences (reference protocol, 16 min 31 s scanning time), (2) three PDFS sequences without STIR (“No STIR”, 12 min 25 s scanning time) and (3) sagittal and axial PDFS sequences plus a coronal STIR sequence (“No PDFS”, 11 min 49 s scanning time). Agreement of the readings using both subsets of sequences compared to the reference protocol was evaluated using weighted kappa statistics. κ-coefficients showed good or excellent agreement for both sequence subsets in comparison to the reference protocol for all assessed features. κ-coefficients for No PDFS/No STIR: bone marrow abnormalities (0.74/0.67), subarticular cysts (0.84/0.63), marginal osteophytes (0.77/0.71), menisci (0.75/0.79), tibial cartilage (0.71/0.78). Optimization of sequence protocols consisting of three sequences results in time savings and cost efficiency in imaging of knee OA without loss of information over a more time consuming protocol.

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Acknowledgements

The Multicenter Osteoarthritis Study (MOST) is a 7-year cooperative epidemiological study of knee osteoarthritis funded by the National Institute on Aging (NIA) within the National Institutes of Health (NIH).

NIA grant numbers: U01 AG18820, U01 AG19069, U01 AG18832, U01 AG18947.

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Authors and Affiliations

  1. Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, CA, USA

    Frank W. Roemer, Ali Guermazi, John A. Lynch, Jing Li, Andreas Mohr & Harry K. Genant

  2. Synarc, Inc, San Francisco, CA, USA

    Ali Guermazi, Charles G. Peterfy & Harry K. Genant

  3. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA

    Michael C. Nevitt

  4. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Nita Webb

  5. Department of Radiology, University of Schleswig-Holstein, Campus Kiel, Germany

    Andreas Mohr

  6. Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, USA

    David T. Felson

  7. Department of Radiology, Klinikum Augsburg, Stenglinstr 2, 86156, Augsburg, Germany

    Frank W. Roemer

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  1. Frank W. Roemer
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  2. Ali Guermazi
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  3. John A. Lynch
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  4. Charles G. Peterfy
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  5. Michael C. Nevitt
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  7. Jing Li
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  8. Andreas Mohr
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  9. Harry K. Genant
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  10. David T. Felson
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Correspondence to Frank W. Roemer.

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Roemer, F.W., Guermazi, A., Lynch, J.A. et al. Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol. Eur Radiol 15, 978–987 (2005). https://doi.org/10.1007/s00330-004-2608-6

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  • DOI: https://doi.org/10.1007/s00330-004-2608-6

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