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Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis

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Abstract

Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to assess associations of IRF5 gene polymorphisms with rheumatoid arthritis risk. Meta-analysis was performed on six published case–control studies (from eight countries) that included 4,818 cases of rheumatoid arthritis and 4,316 controls. The rs2004640-T allele was associated with a significantly increased risk of rheumatoid arthritis when the dominant genetic model was applied (T/T + T/G versus G/G: P = 0.003, OR = 1.14, 95 % CI 1.05–1.25). Upon stratified analysis by ethnicity, the rs2004640 polymorphism was associated with an increased rheumatoid arthritis risk in Caucasians when the homozygotic contrast model was employed(T/T versus G/G: P = 0.03, OR = 1.25, 95 % CI 1.02–1.53) and this was also the case when the dominant genetic model was used (T/T + T/G versus G/G: P = 0.04, OR = 1.20, 95 % CI 1.01–1.42), whereas, in Asian populations, only the dominant genetic model was associated with an increased rheumatoid arthritis risk (T/T + T/G versus G/G: P = 0.02, OR = 1.14, 95 % CI 1.02–1.26). The results suggest that the IRF5 rs2004640 polymorphism is associated with rheumatoid arthritis especially when the dominant genetic model is applied.

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Acknowledgments

This work was supported by the Fund of Heilongjiang Provincial Education Department (12521180), the Fund of Heilongjiang Province Postdoctoral Project (313000075),the Fund of Heilongjiang Provincial Health Office (2011-208), the Fund of “Spring Sunshine Program” (Z2010003), and the Fund of HarBin Science and Technology Bureau (RC2011XK003008). We thank Dr. Philippe Dieudé and Dr.Y Kochi for their kindly data sharing.

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The authors declare no potential conflicts of interest.

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Correspondence to Xiuzhi Jia.

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Xiuzhi Jia and Minghui Hu contributed equally to the research.

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296_2013_2806_MOESM1_ESM.ppt

Supplementary Figure 1 Forest plot for the association between IRF5 rs2004640 polymorphism and rheumatoid arthritis risk in all subjects in dominant genetic model. (PPT 160 kb)

296_2013_2806_MOESM2_ESM.ppt

Supplementary Figure 2 Forest plot for the association between IRF5 rs2004640 polymorphism and rheumatoid arthritis risk in Caucasian population in dominant genetic model. (PPT 150 kb)

296_2013_2806_MOESM3_ESM.ppt

Supplementary Figure 3 Forest plot for the association between IRF5 rs2004640 polymorphism and rheumatoid arthritis risk in Caucasian population in homozygote contrast model. (PPT 148 kb)

296_2013_2806_MOESM4_ESM.ppt

Supplementary Figure 4 Forest plot for the association between IRF5 rs2004640 polymorphism and rheumatoid arthritis risk in Asian population in dominant genetic model. (PPT 144 kb)

296_2013_2806_MOESM5_ESM.ppt

Supplementary Figure 5 Funnel plot of studies for the association between the rs2004640 polymorphism and rheumatoid arthritis in dominant genetic model in all subjects. (PPT 133 kb)

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Jia, X., Hu, M., Lin, Q. et al. Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis. Rheumatol Int 33, 2757–2761 (2013). https://doi.org/10.1007/s00296-013-2806-0

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