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Association of macrophage migration inhibitory factor gene −173 G/C polymorphism with prognosis in turkish children with juvenile rheumatoid arthritis

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Abstract

The objectives of this study were to determine genotypic and allelic frequencies of macrophage migration inhibitory factor (MIF) gene −173 G/C polymorphism in patients with juvenile rheumatoid arthritis (JRA) and to evaluate the association of the MIF −173 C allele with the outcome of JRA. Genomic DNA was collected from 67 JRA patients and 153 healthy individuals. To evaluate the association of the MIF −173 polymorphism with the outcome, we analyzed the data concerning the treatment regimen, duration of glucocorticoid treatment, score on the childhood health assessment questionnaire (C-HAQ) and the number of joints with active arthritis. Nonsignificant differences were observed between the study and control groups in the distribution of genotype and allele frequencies of the MIF gene −173 G/C polymorphism. In JRA patients, carrying a MIF −173 C allele, the number of disease modifying antirheumatic drugs required for the treatment was more, the duration of glucocorticoid treatment was significantly longer, and at the last visits the C-HAQ scores and the number of joints with active arthritis were significantly higher. MIF gene −173 C allele frequency did not differ between the controls and JRA patients. MIF −173 C allele did not confer increased susceptibility to JRA in our study group. Carriage of the MIF −173 C allele was found to be a strong predictor of poor outcome in all types of JRA.

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Authors and Affiliations

  1. Department of Pediatrics, Laboratory of Molecular Medicine, Ege University School of Medicine, Bornova, 35100, Izmir, Turkey

    Afig Berdeli

  2. Department of Pediatrics, Ege University, Izmir, Turkey

    Arif Ruhi Özyürek, Zülal Ülger, Dolunay Gürses & Ertürk Levent

  3. Department of Pediatrics, SSK Tepecik Hospital, Izmir, Turkey

    Koray Salar & Ali Rahmi Gürpınar

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  1. Afig Berdeli
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  2. Arif Ruhi Özyürek
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  3. Zülal Ülger
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  4. Dolunay Gürses
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  5. Ertürk Levent
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  6. Koray Salar
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  7. Ali Rahmi Gürpınar
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Correspondence to Afig Berdeli.

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Berdeli, A., Özyürek, A.R., Ülger, Z. et al. Association of macrophage migration inhibitory factor gene −173 G/C polymorphism with prognosis in turkish children with juvenile rheumatoid arthritis. Rheumatol Int 26, 726–731 (2006). https://doi.org/10.1007/s00296-005-0062-7

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  • DOI: https://doi.org/10.1007/s00296-005-0062-7

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