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Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus

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Abstract

A link between Epstein-Barr Virus (EBV) and systemic lupus erythematosus (SLE) has been suggested. However, recent advances in molecular technology now permit more detailed analysis. Sera from SLE patients were tested for antibodies to several EBV antigens and had a significantly higher prevalence of immunoglobulin G antibodies against EBV early antigens than in normal or disease controls. This suggests that recent EBV infection or virus reactivation was occurring in these patients.

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Fig. 1a–e

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Acknowledgements

We are grateful to the Jones Charitable Trust for funding.

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Authors and Affiliations

  1. Division of Immunology, School of Molecular Medical Sciences, University of Nottingham, Queen’s Medical Centre, A Floor West Block, Nottingham NG7 2UH, U.K.

    Mary L. Huggins, Ian Todd & Richard J. Powell

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  1. Mary L. Huggins
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  2. Ian Todd
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  3. Richard J. Powell
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Correspondence to Mary L. Huggins.

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Huggins, M.L., Todd, I. & Powell, R.J. Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus. Rheumatol Int 25, 183–187 (2005). https://doi.org/10.1007/s00296-003-0420-2

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  • DOI: https://doi.org/10.1007/s00296-003-0420-2

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