Abstract
This study analyses the clinical, radiological, evolutive, and immunogenetical characteristics of a series of patients diagnosed with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Reviewed were the clinical charts and human leukocyte antigen (HLA) profiles of all patients treated at a single teaching hospital fulfilling the features of this syndrome according to the definition of McCarty. Twelve cases were detected in ten men and two women aged from 62 to 85 years. Rheumatoid factor was negative in all cases, and antinuclear antibodies (ANA) were positive in two. All patients achieved complete resolution of their condition within 1 year with glucocorticoid (GC) use. Two relapsed after remission but responded again to low doses of GC. Four patients showed clinical and electrodiagnostic studies consistent with carpal tunnel syndrome. No specific HLA association could be found in this report. To date, none of these patients has developed definite rheumatic diseases, infections, or malignant diseases. Although the real nature of the syndrome is still a matter of debate, at least in our context, RS3PE remains a definite condition with an excellent prognosis.
Similar content being viewed by others
References
McCarty DJ, O'Duffy JD, Pearson L, Hunter JB (1985) Remitting seronegative symmetrical synovitis with pitting edema. RS3PE syndrome. JAMA 254:2763–2767
Russell EB, Hunter JB, Pearson L, McCarty DJ (1990) Remitting, seronegative, symmetrical synovitis with pitting edema. 13 additional cases. J Rheumatol 17:633–639
Sibilia J, Friess S, Schaeverbeke T, Maloisel F, Bertin P, Goichot B et al (1999) Remitting seronegative symmetrical synovitis with pitting edema (RS3PE): a form of paraneoplastic polyarthritis? J Rheumatol 26:115–120
Olive A, del Blanco J, Pons M, Vaquero M, Tena X (1997) The clinical spectrum of remitting seronegative symmetrical synovitis with pitting edema. The Catalan Group for the Study of RS3PE. J Rheumatol 24:249–252
Mouly S, Berenbaum F, Kaplan G (2001) Remitting seronegative symmetrical synovitis with pitting edema following intravesical bacillus Calmette-Guerin instillation. J Rheumatol 28:1699–1701
Torres A, Cuende E, De Pablos M, Lezaun MJ, Michaus L, Vesga JC (2001) Remitting seronegative symmetrical synovitis with pitting edema associated with subcutaneous Streptobacillus moniliformis abscess. J Rheumatol 28:1696–1698
Schaeverbeke T, Fatout E, Marce S, Vernhes JP, Halle O, Antoine JP et al (1995) Remitting seronegative symmetrical synovitis with pitting edema: disease or syndrome? Ann Rheum Dis 54:681–684
Gregersen PK, Silver J, Winchester RJ (1987) The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205–1213
Weyand CM, Hunder NN, Hicok KC, Hunder GG, Goronzy JJ (1994) HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis. Arthritis Rheum 37:514–520
Toussirot E, Berthier S, Wendling D, Tiberghien P (1998) Lack of association between HLA DRB1* alleles and RS3PE syndrome. Ann Rheum Dis 57:442
Cedoz JP, Wendlin D, Viel JF (1995) The B7 cross-reactive group and spondyloarthropathies: an epidemiological approach. J Rheumatol 22:1184–1190
Olivieri I, Padula A, Pierro A, Favaro L, Oranges GS, Ferri S (1995) Late onset undifferentiated seronegative spondyloarthropathy. J Rheumatol 22:899–903
Cantini F, Salvarani C, Olivieri I, Barozzi L, Macchioni L, Niccoli L et al (1999) Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome: a prospective follow up and magnetic resonance imaging study. Ann Rheum Dis 58:230–236
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Queiro, R. RS3PE syndrome: a clinical and immunogenetical study. Rheumatol Int 24, 103–105 (2004). https://doi.org/10.1007/s00296-003-0330-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-003-0330-3