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Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese Population-based Osteoporosis (JPOS) Study

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Abstract

The present study was conducted as a part of the Japanese Population-based Osteoporosis (JPOS) Study to establish reference values on the biochemical markers of bone turnover in the general Japanese female population over an applicable age range. The study recruited 3250 women aged 15–79 years, randomly selected from five municipalities throughout Japan, and obtained measurements of serum osteocalcin (OC) and bone-specific alkaline phosphatase (BAP); free and total forms of immunoreactive deoxypyridinoline, free pyridinolines and type I collagen cross-linked C-terminal telopeptide (CTx) in urine; serum intact parathyroid hormone (PTH) and 1,25 dihydroxy vitamin D (1,25 (OH)2D); and bone density at the spine, hip and distal forearm. After excluding subjects with apparent or suggested abnormalities affecting bone mass, 2535 (78%) subjects were further analyzed. The authors presented 5-year age-specific mean values of the markers and mean marker levels derived from women aged 30–44 years with normal bone density as a healthy young adult reference. Values of the markers decreased with increasing age before the age of 40, increased steeply among subjects in their 50s, and remained elevated in the elderly. Serum calcium, phosphorus, PTH and 1,25 (OH)2D levels were higher in postmenopausal women than in premenopausal women. However, 1,25 (OH)2D was lower among early postmenopausal subjects. The levels of OC, BAP, CTx, PTH and 1,25(OH)2D were significantly greater for women with osteoporosis than for those without. The diagnostic value of the markers was limited as the sensitivity and specificity ranged from 55% to 60%. These findings will aid health professionals in the correct assessment of bone turnover status in Japanese women over a wide range of age.

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Acknowledgements

This study was conducted by the JPOS Study Group comprising Fumiaki Marumo (Chairman of the Study Group, Tokyo Medical and Dental University), Toshihisa Matsuzaki (Co-chairman of the Study Group, Institute of Comprehensive Community Care), Etsuko Kajita (Nagoya University School of Health Sciences), Tomoharu Matsukura (Kanazawa University), Yuho Sato (Tenshi College) and Takashi Yamagami (Hokuriku Health Service Association) along with the authors. Financial support was provided by the Japan Milk Promotion Board, and the Japan Dairy Council. The authors wish to express special thanks to the personnel of the health department of the five municipalities used in the investigation for their excellent support of the study, and SRL Inc., Tachikawa, Tokyo, Japan, for their technical assistance in laboratory tests.

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Authors and Affiliations

  1. Department of Public Health, Kinki University School of Medicine , 377-2 Oono-Higashi, Osaka-Sayama, 589-8511, Osaka, Japan

    Masayuki Iki

  2. Department of Blood Purification and Internal Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan

    Takashi Akiba

  3. Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan

    Toshio Matsumoto

  4. Toyama Red Cross Blood Center, Toyama, Japan

    Harumi Nishino

  5. Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University, Toyama, Japan

    Sadanobu Kagamimori

  6. Kagawa Nutrition University, Tokyo, Japan

    Yoshiko Kagawa

  7. Shuuwa General Hospital, Kasukabe, Japan

    Hideo Yoneshima

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  1. Masayuki Iki
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  3. Toshio Matsumoto
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Correspondence to Masayuki Iki.

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Iki, M., Akiba, T., Matsumoto, T. et al. Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese Population-based Osteoporosis (JPOS) Study. Osteoporos Int 15, 981–991 (2004). https://doi.org/10.1007/s00198-004-1634-1

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  • DOI: https://doi.org/10.1007/s00198-004-1634-1

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