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Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis

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Summary

Compared with normal cartilage, the water content, extraction yields, and capacity of34SO4 incorporation, were found to be increased in articular cartilage from rheumatoid joints, which also synthesizes an increased proportion of low and middle density small size proteoglycans (PGs), enriched in dermatan sulfate. These small [35S]-PGs also possess longer glycosaminoglycan side chains and lack the ability to interact with hyaluronan. An altered pattern of PG synthesis of rheumatoid chondrocytes may contribute to cartilage damage in this condition.

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Authors and Affiliations

  1. U-18 INSERM, Lariboisière Hospital, 6 rue Guy Patin, F-75010, Paris, France

    D. R. Mitrovic & N. Darmon

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  1. D. R. Mitrovic
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  2. N. Darmon
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Mitrovic, D.R., Darmon, N. Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis. Rheumatol Int 10, 31–37 (1990). https://doi.org/10.1007/BF02274778

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  • DOI: https://doi.org/10.1007/BF02274778

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