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Clinical correlation of anticentromere antibodies

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Summary

A retrospective survey of all patients with a positive anticentromere antibody (ACA) determination was undertaken over a 3-years period of time in a university hospital. Forty-five patients were positive for anticentromere antibodies. The analysis of the clinical characteristics and diagnoses of the patients with anticentromere antibodies were correlated and showed a diverse array of symptoms. Only 4.4% had CREST syndrome, 6.7% had limited scleroderma, 17.8% had diffuse scleroderma, 20% had other connective tissue diseases, 20% had other miscellaneous rheumatic conditions, 11.1% had tumours and 20% other nonrheumatic diseases. The study shows that the presence of ACA, as detected during routine ANA-testing, does not strongly suggest a diagnosis of CREST at that time. The presence of a scleroderma-variant in almost 50% of the patients and the occurrence of Raynaud's phenomenon in 62% underscores, however, an association of ACA with (early) scleroderma-like disorders.

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Authors and Affiliations

  1. German Research Center for Rheumatology, Nordufer 20, 13353, Berlin, Germany

    M. Zuber

  2. Department of Internal Medicine, Steglitz University Medical Center, Hindenburgdamm 30, 12200, Berlin, Germany

    R. Gotzen & I. Filler

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  2. R. Gotzen
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  3. I. Filler
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Zuber, M., Gotzen, R. & Filler, I. Clinical correlation of anticentromere antibodies. Clin Rheumatol 13, 427–432 (1994). https://doi.org/10.1007/BF02242937

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