Summary
Circulating sICAM-1 is known to be elevated in various inflammatory disorders. It is further suggested that elevated levels correlate well with disease activity in several autoimmune disorders. The objectives of this study are to determine the serum sICAM-1 levels in patients with systemic lupus erythematosus (SLE) and correlate sICAM-1 levels with clinical and laboratory (ESR, CRP, anti-dsDNA) measures of disease activity. Forty-one patients (34 female, 7 male) all fulfilling 1982 ARA classification criteria for SLE and 16 healthy controls (8 female, 8 male) were included in the study. Disease activity was measured according to SLEDAI. sICAM-1 was determined by ELISA. Mean sICAM-1 in SLE patients (339±161 ng/ml) were significantly higher than in the controls (216±85 ng/ml) (p<0.005). Although slightly elevated in active patients, there was no statistically significant difference between mean sICAM-1 levels of active and inactive SLE patients (349±183 ng/ml and 316±103 ng/ml respectively) (p>0.05). We could not find a correlation between sICAM-1 levels and any organ involvements. Similarly, no significant correlation was found between ESR, CRP, anti-ds-DNA and sICAM-1. These results suggest that although higher than normal, sICAM-1 levels in SLE do not provide additional information over conventional activity markers.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albelda SM. Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol 1991, 4, 195–203.
Montefort S, Holgate ST. Adhesion molecules and their role in inflammation. Respiratory Med 1991, 85, 91–99.
Cronstein BN, Weismann G. The adhesion molecules of inflammation. Arthritis Rheum 1993, 36, 147–157.
Mackay CR, Imhof BA. Cell adhesion in the immune system. Immunol Today 1993, 14, 99–102.
Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986, 137, 1270–1274.
Dougherty GJ, Murdoch S, Hogg N. The function of human intercellular adhesion molecule-1 (ICAM -1) in the generation of immune response. Eur J Immunol 1988, 18, 35–39.
Rothlein R, Mainolfi EA, Czajkowski M, Marlin SD. A form of circulating ICAM-1 in human serum. J Immunol 1991, 147, 3788–3793.
Seth R, Raymond FD, Makgoba MW. Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 1991,338, 83–84.
Sujisaki M, Imai K, Hirata H, Hanzawa Y, Masuya J, Nakano T, Sugiyama T, Matsui M, Hinoda Y, Yachi A. Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol 1991, 85, 3–8.
Furukawa S, Imai K, Matsubara T, Yone K, Yachi A, Okumura K, Yabuta K. Increased levels of circulating intercellular adhesion molecule-1 in Kawasaki disease. Arthritis Rheum 1992, 35, 672–677.
Heufelder AE, Bahn RS. Soluble intercellular adhesion molecule-1 (sICAM-1) in sera of patients with Graves' ophthalmopathy and thyroid diseases. Clin Exp Immunol 1993, 92, 296–302.
Hashimato S, Imai K, Kobayashi T, Anemiya E, Takahashi Y, Tomita Y, Iwata T, Suguro H, Yamaguchi M, Yachi A, Horie T. Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma. Allergy 1993, 48, 370–372.
Gundel RH, Wegner CD, Torcellini CA, Letts LG. The role of intercellular adhesion molecule-1 in chronic airway inflammation. Clin Exp Allergy 1992, 22, 569–575.
Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield FN, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.
American Rheumatism Association Glossary Committee. Signs and symptoms. Dictionary of the Rheumatic Disease 1982, 1, 1–80.
Petri M, Hellmann D, Hochberg M. Validity and reliability of lupus activity measures in the routine clinic setting. J Rheumatol 1992, 19, 53–59.
Cush JJ, Rothlein R, Lindsley HB, Mainolfi EA, Lipsky PE. Increased levels of circulating intercellular adhesion molecule 1 in the sera of patients with rheumatoid arthritis. Arthritis Rheum 1993, 36, 1098–1102.
Machold KP, Keiner PH, Graninger W, Graninger WB. Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol 1993, 68, 74–78.
Mason CJ, Kapahi P, Haskard DD. Detection of increased levels of circulating intercellular adhesion molecule 1 in some patients with rheumatoid arthritis but not in patients with systemic lupus erythematosus. Arthritis Rheum 1993, 36, 519–527.
Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL-1 and IFN gamma: Tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J Immunol 1986, 137, 245–255.
Aoki S, Imas K, Yachi A. Soluble intercellular adhesion molecule-1 (ICAM-1) antigen in patients with rheumatoid arthritis. Scand J Immunol 1993, 38, 485–490.
Sfikakis PP, Charalambopoulos D, Vayiopoulos G, Oglesby R, Sfikakis P, Tsokos GC. Increased levels of intercellular adhesion molecule-1 in the serum of patients with systemic lupus erythematosus. Clin Exp Rheumatol 1994, 12, 5–9.
Brennan FM, Feldman M. Cytokines in autoimmunity. Curr Opin Immunol 1992, 4, 754–759.
Tsokas GC, Arnett FC, Linker-Israeli M, Winfield JB, Mimura T, Lahita RG, Steinberg AD. Symposium in writing. Pathogenesis of human systemic lupus erythematosus. Clin Immunol Immunopathol 1992, 63, 3–22.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tülek, N., Aydintuğ, O., Özoran, K. et al. Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with systemic lupus erythematosus. Clin Rheumatol 15, 47–50 (1996). https://doi.org/10.1007/BF02231684
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02231684