Summary
Ninety systemic sclerosis (SSc) patients, all females, none of them suffering from either renal failure or intestinal malabsorption, and 90 sex and age matched controls were investigated for bone mineral content (BMC) by dual photon-absorptiometry (Am 241, I 125) (Osteoden P, NIM) evaluated at two sites of the nondominant radius. BMC as well as bone density (BD) were found to be significantly lower in the patients than in the controls. No alteration of calcium metabolism was detected in the patients, neither were we able to find any relationship between osteopenia and the extent of the involvement of the skin or of any internal organ. We observed, however, that the percentage of the patients in menopause was significantly greater than that of the controls (p<.001). Furthermore, menopause had occurred in the patients significantly earlier than in the controls (p<.001). Therefore, earlier menopause can play a role in the induction of osteopenia in systemic sclerosis. Further prospective studies are needed to check the hormonal status of SSc patients.
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Medsger, T.A. jr. Systemic Sclerosis (Scleroderma), Localized Scleroderma, Eosinophilic Fasciitis and Calcinosis. Ed.: McCarty, D.J., Arthritis and Allied Conditions. 11th ed. Philadelphia, Lea and Febiger, 1989, pp. 1118–1165.
Seibold, J.R. Scleroderma. Eds: Kelley, W.N., Harris, E.D., Ruddy, S., Sledge, C.B. In: Textbook of Rheumatology, Saunders, W.B. Co, 3rd ed., 1989, pp. 1215–1244.
Tuffanelli, D.L., Winkelmann, R.K. Systemic scleroderma. Arch Dermatol 1961, 84, 49–61.
Blocka, K.L.N., Basset, L.W., Furst, D.E., Clements, P.J., Paulus, H.E. The arthropathy of advanced progressive systemic sclerosis: a radiographic survey. Arthritis Rheum 1981, 24, 874–884.
Serup, J., Hagdrup, H., Tvedegaard, E. Bone mineral content in systemic sclerosis measured by photonabsorptiometry. Acta Dermatovener 1983, 63, 235–237.
La Montagna, G., Vatti, M., Valentini, G. Bone mineral content in progressive systemic sclerosis (PSS). Preliminary report. Fifth Eular Workshop on Rheumatology Research, Milan, March 1–2, 1985. Abstract Book 3,4.
Avioli, L.V. Osteoporosis. Ed: Peck, W.A. In Bone and Mineral Research. Annual 1. Amsterdam, Excerpta Medica, 1983, pp. 280–318.
Subcommittee for scleroderma criteria of the American Rheumatism Asscciation diagnostic and therapeutic criteria committee: Preliminary criteria for classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980, 23, 581–590.
Giordano, M., Valentini, G., Migliaresi, S., Picillo, U., Vatti, M. Different antibody patterns and different prognoses in patients with scleroderma with various extents of skin sclerosis. J Rheumatol 1986, 13, 911–916.
La Montagna, G., Vatti, M., Valentini, G., Giordano, M. Contenu mineral osseux dans la sclerose systemique (SSc): un etude de 65 cas, VII Rheumatological Congressus Latinus, Torremolinos octobre 1986, Abstract Book.
Mazess, R.B. The noninvasive measurement of skeletal mass. Ed: Peck, W.A. In: Bone and Mineral Research, Excerpta Medica, Amsterdam, 1983, pp. 223–279.
Serup, J., Hagdrup, H.K. Parathyroid hormone and calcium metabolism in generalized scleroderma. Acta Dermatol Res 1986, 13, 43–46.
Aloia, J.F., Vaswani, A., Ellis, K., Yuen, K., Cohn, S. A model for involutional bone loss. J Lab Clin Med 1985, 106, 630–637.
Verstraeten, A., Dequeker, J. Mineral metabolism in postmenopausal women with active rheumatoid arthritis, J Rheumatol 1986, 13, 43–46.
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La Montagna, G., Vatti, M., Valentini, G. et al. Osteopenia in systemic sclerosis. Evidence of a participating role of earlier menopause. Clin Rheumatol 10, 18–22 (1991). https://doi.org/10.1007/BF02208027
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DOI: https://doi.org/10.1007/BF02208027