Summary
We compared, in a double blind, randomized, 3-center study, a pulse of 1000 mg methylprednisolone with a pulse of 250 mg methylprednisolone, in patients with active rheumatoid arthritis. Improvement of patients was similar in both groups and lasted up to 3 weeks. Side effects were minor.
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References
Hess, E.V., Kammen, P.L. Pulse therapy in rheumatoid arthritis. Ann Intern Med, 1981, 94, 128–129.
Liebling, M.R., et. al. Pulse methylprednisolone in rheumatoid arthritis. Ann Intern Med, 1981, 94, 21–26.
Williams, I.A., Baylis, E.M., Shipley, M.E. A double-blind placebo-controlled trial of methylprednisolone pulse therapy in active rheumatoid disease. Lancet, 1982, ii, 237–239.
Detsky, A.S., Sackett, D.L. When was a “negative” clinical trial big enough? Arch Intern Med, 1985, 145, 709–712.
Garber, E.K., Fan, P.T., Bluestone, R. Realistic guidelines of corticosteroid therapy in rheumatic disease. Semin Arthritis Rheum 1981, 11, 231–256.
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Vischer, T.L., Sinniger, M., Ott, H. et al. A randomized, double-blind trial comparing a pulse of 1000 with 250 mg methylprednisolone in rheumatoid arthritis. Clin Rheumatol 5, 325–326 (1986). https://doi.org/10.1007/BF02054249
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DOI: https://doi.org/10.1007/BF02054249