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The uptake mechanisms of inflammation-and infection-localizing agents

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Abstract

Over the past 30 years, a wide variety of radiopharmaceuticals have been proposed for the scintigraphic detection of inflammatory and infectious disease. All radiopharmaceuticals yield a functional image of a process placed somewhere in the cascade of reactions in inflammation, this being the common pathway of response to tissue injury. This paper discusses relevant aspects of the biodistribution, in vivo kinetics and mechanisms of uptake of both clinically used and experimental radiopharmaceuticals that have been proposed for the scintigraphic detection of focal inflammation and infection.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Wim J. G. Oyen, Otto C. Boerman, Conny J. van der Laken, Roland A. M. J. Claessens & Frans H. M. Corstens

  2. Department of Internal Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands, The Netherlands

    Jos W. M. van der Meer

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  1. Wim J. G. Oyen
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  2. Otto C. Boerman
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  6. Frans H. M. Corstens
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Oyen, W.J.G., Boerman, O.C., van der Laken, C.J. et al. The uptake mechanisms of inflammation-and infection-localizing agents. Eur J Nucl Med 23, 459–465 (1996). https://doi.org/10.1007/BF01247377

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