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Stimulation of anti-RNP antibody binding to cultured keratinocytes by estradiol

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Summary

Antibodies to extractable nuclear antigens (ENA) are frequently demonstrated in the serum of patients with cutaneous lupus erythematosus. To gain a better understanding of the influence of sex hormones on cutaneous lupus, we investigated the in vitro binding of anti-ENA antibodies to cultured human keratinocytes. Estradiol-Β augmented the binding of anti-RNP, anti-SS-A/Ro, and anti-SS-B/La antibodies to cultured cells, but produced no enhancement of the binding of anti-Sm antibodies. In addition, we examined the effects of 16-α-hydroxyestrone, a highly estrogenic metabolite, on the binding of anti-ENA antibodies to cultured cells. This agent did not produce any augmentation of binding. Based on these experiments, we discuss the influence of estradiol on cutaneous lupus.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Kyoto University, Shogoin, Sakyo, 606, Kyoto, Japan

    F. Furukawa & S. Imamura

  2. Department of Dermatology, University of Colorado School of Medicine, USA

    F. Furukawa & D. A. Norris

  3. Denver Veterans Administration Hospital, USA

    D. A. Norris

Authors
  1. F. Furukawa
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  2. S. Imamura
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  3. D. A. Norris
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Furukawa, F., Imamura, S. & Norris, D.A. Stimulation of anti-RNP antibody binding to cultured keratinocytes by estradiol. Arch Dermatol Res 283, 258–261 (1991). https://doi.org/10.1007/BF01106112

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  • DOI: https://doi.org/10.1007/BF01106112

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