Abstract
A report of two patients in which a soft tissue mass, initially regarded as a malignant tumor, was shown to be the result of calcium pyrophosphate deposition disease. The first case, a woman aged 71 years, presented with a mass involving the right fifth finger. In the second case, also a women aged 71 years, the lesion involved the tissues adjacent to the right hip. Each lesion consisted of a mass of highly cellular tissue containing deposits of calcium pyrophosphate dihydrate crystals. the clinical, radiological, and pathological features of the two cases are compared with those of seven similar cases reported in the literature.
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Annamunthodo H (1960) Calcinosis. Am J Surg 99:951
Baldursson H, Evans EB, Dodge WF, Jackson WT (1969) Tumoral calcinosis with hyperphosphatemia. A report of a family with incidence in four siblings. J Bone Joint Surg [Am] 51:913
Barton DL, Reeves RJ (1961) Tumoral calcinosis. Report of three cases and review of the literature. AJR 86:351
Boskey AL, Vigorita VJ, Sencer O, Stuchin SA, Lane JM (1983) Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis. Clin Orthop 178:258
Bostrom B (1981) Tumoral calcinosis in an infant. Am J Dis Child 135:246
Doyle DV, Dieppe PA, Crocker PR, Ibe K, Willoughby DA (1977) Mixed crystal deposition in an osteoarthritic joint. J Pathol 123:1
Dryll A, Bardin T, Lansaman J, Tran Van P, Hard H, Ryckewaert A, Cywiner-Golenzer C (1984) Tumoral calcinosis. Light and electron microscopic study with electron diffraction and X-ray microanalysis of the mineral deposit. J Submicrosc Cytol 16:577
Duret H (1899) Tumeurs multiples et singulières des bourses sereuses. Bull Mem Soc Anat Paris 74:725
El-Khoury GY, Foucar E, Blair WF, Strottman MP, Malvitz TA, Smoker WRK (1986) Massive calcium pyrophosphate dihydrate crystal deposition disorder involving thumb. Skeletal Radiol 15:313
Frühwald F, Kovarik J, Neuhold A, Seidl G (1983) Tumorartige Schleimbeutelverkalkungen infolge unkontrollierbarer Hyperphosphatämie bei chronischer Hämodialyse. Radiologe 23:529
Ghormley RK, McCrary WE (1942) Multiple calcified bursae and calcified cysts in soft tissues. Trans Western Surg Assoc 51:292
Halverson PB, McCarty DJ (1986) Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the knee. Ann Rheum Dis 45:603
Hensley CD, Lin JJ (1984) Massive intrasynovial deposition of calcium pyrophosphate in the elbow. J Bone Joint Surg [Am] 66:133
Inclan A, Leon P, Camejo MG (1943) Tumoral calcinosis. JAMA 121:490
Knowles SAS, Declerck G, Anthony PP (1983) Tumoral calcinosis. Br J Surg 70:105
Lafferty FW, Reynalds ES, Pearson OH (1965) Tumoral calcinosis. A metabolic disease of obscure etiology. Am J Med 38:105
Lagier R, Boivin G, Gerster JC (1984) Carpal tunnel syndrome associated with mixed calcium pyrophosphate dihydrate and apatite crystal deposition in tendon synovial sheath. Arthritis Rheum 27:1190
Leisen J (1982) Calcium pyrophosphate dihydrate deposition disease: Tumorous form. AJR 138:962
Leisen JCC, Austad ED, Bluhm GB, Sigler JW (1980) The tophus in calcium pyrophosphate deposition disease. JAMA 244:1711
Ling D, Murphy WA, Kyriakos M (1982) Tophaceous pseudogout. AJR 138:162
Lichtenstein L, Scott HW, Levin MH (1956) Pathologic changes in gout. Survey of eleven necropsied cases. Am J Pathol 32:871
Lyles KW, Burkes EJ, Ellis GJ, Lucas KJ, Dolan EA, Drezner MK (1985) Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity. J Clin Endocrinol Metab 60:1093
Marcove RC, Wolfe SW, Healey JH, Huvos AG, Boskey A, Fleisher M (1988) Massive solitary tophus containing calcium pyrophosphate dihydrate crystals at the acromioclavicular joint. Clin Orthop 227:305
Markel SF, Hart WR (1982) Arthropathy in calcium pyrophosphate dihydrate crystal deposition disease. Pathologic study of 12 cases. Arch Pathol Lab Med 106:529
McCarty JD (1977) Calcium pyrophosphate crystal deposition disease. In: McCarty DJ (ed) Arthritis and allied conditions. Lea and Febiger, Philadelphia
McCarty DJ, Kohn NN, Faires JS (1962) The significance of calcium phosphate crystals in the synovial fluid of arthritic patients. The “pseudogout syndrome”. Ann Intern Med 56:711
McCarty DJ, Hogan JM, Gatter RA, Grossman M (1966) Studies of pathological calcifications in human cartilage. Prevalence and types of crystal deposits in the menisci of 215 cadavera. J Bone Joint Surg [Am] 48:309
Menkes CJ, Simon F, Delrieu F, Forest M, Delbarre F (1976) Destructive arthropathy in chondrocalcinosis articularis. Arthritis Rheum 19:329
Nora FE, Dahlin DC, Beabout JW (1983) Bizarre parosteal osteochondromatous proliferations of the hands and feet. Am J Surg Pathol 7:245
Prince MJ, Schaeffer PC, Goldsmith RS, Chausmer AB (1982) Hyperphosphatemic tumoral calcinosis. Ann Intern Med 96:586
Pritzker KPH, Phillips H, Luk SC, Koven IH, Kiss A, Houpt JB (1976) Pseudotumor of temporomandibular joint. Destructive calcium pyrophosphate dihydrate arthropathy. J Rheumatol 3:70
Reginato AJ, Hollander JL, Martinez V, Valenzuela F, Schiapachasse V, Covarrubias E, Jacobelli S, Arinoviche R, Silcox D, Ruiz F (1975) Familial chondrocalcinosis in the Chiloe Islands, Chile. Ann Rheum Dis 34:260
Resnick D, Niwayama G (1988) Gouty arthritis. In: Resnick D, Niwayama G (eds) Diagnosis of bone and joint disorders, 2nd edn. Saunders, Philadelphia
Slavin G, Klenerman L, Darby A, Bansal S (1973) Tumoral calcinosis in England. Br Med J [Clin Res] 1:147
Steinherz R, Chesney RW, Eisenstein B, Metzker A, DeLuca HF, Phelps M (1985) Elevated serum calcitriol concentrations do not fall in response to hyperphosphatemia in familial tumoral calcinosis. Am J Dis Child 139:816
Walker GS, Davison AM, Peacock M, McLachlan MS (1977) Tumoral calcinosis: a manifestation of extreme metastatic calcification occurring with 1 alpha-hydroxycholecalciferol therapy. Postgrad Med J 53:570
Wilber JF, Slatopolsky E (1968) Hyperphosphatemia and tumoral calcinosis. Ann Intern Med 68:1044
Zemplenyi J, Calcaterra TC (1985) Chondrocalcinosis of the temporomandibular joint. Arch Otolaryngol III:403
Zitnan D, Sit'aj S (1963) Chondrocalcinosis articularis. Ann Rheum Dis 22:142
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Sissons, H.A., Steiner, G.C., Bonar, F. et al. Tumoral calcium pyrophosphate deposition disease. Skeletal Radiol 18, 79–87 (1989). https://doi.org/10.1007/BF00350651
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DOI: https://doi.org/10.1007/BF00350651