Abstract
B cells at various stages of development and activation undergo specific migration events that are important for their function. A majority of the immature B cells emerging from the bone marrow home to spleen and after a short period of further maturation become competent for migration into B cell follicles. Most B cells join the conventional or B2 subset and recirculate between lymphoid follicles of secondary lymphoid organs. Smaller numbers of cells take a different path, differentiating to B1 cells which preferentially lodge within the body cavities. Following encounter with antigen, conventional B cells redistribute from follicles to T cell zones where they interact with helper T cells. Antigen-stimulated B cells that differentiate to IgM- or IgG-secreting plasma cells leave the T and B cell areas and migrate to splenic red pulp, lymph node medullary cords or bone marrow. Each of these migration events contributes to regulate B cell fate and understanding the factors controlling B cell migration has been a major goal of our work. Here we describe our recent findings showing the roles played by chemokines (Cyster, 1999; Zlotnik and Yoshie, 2000) in controlling the positioning of B cells and plasma cells.
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Cyster, J.G., Ansel, K.M., Ngo, V.N., Hargreaves, D.C., Lu, T.T. (2002). Traffic Patterns of B Cells and Plasma Cells. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_5
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DOI: https://doi.org/10.1007/978-1-4615-0757-4_5
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