Regular ArticleInhibition of Angiogenesis by Somatostatin and Somatostatin-like Compounds Is Structurally Dependent
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Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia
2022, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :In fact, there are several cases that treat refractory GAVE with thalidomide, a potent anti-VEGF agent [25–27]. Octreotide is known to suppress angiogenesis factors in addition to gastrin and has also been shown to have some success in GAVE treatment [27–29]. Metabolic syndrome may help link the presence of cirrhosis in these patients since the major cause of cirrhosis in GAVE patients was NASH: a common presentation in metabolic syndrome.
Systemic Octreotide Therapy in Prevention of Gastrointestinal Bleeds Related to Arteriovenous Malformations and Obscure Etiology in Atrial Fibrillation
2017, JACC: Clinical ElectrophysiologyCitation Excerpt :OCT, a synthetic analogue of somatostatin, has been studied in AVM-related GI bleeding. It acts by inhibition of angiogenesis (24). Indeed, disappearance or decrease in the size of AVMs has been reported with OCT therapy (25).
Gastrointestinal Angiodysplasia: Diagnosis and Management
2017, Gastrointestinal Endoscopy Clinics of North AmericaCitation Excerpt :Somatostatin analogues constitute a proposed medical therapy for symptomatic GIAD.38 There are several mechanisms for the effect of somatostatin analogues, including inhibition of angiogenesis, decreased duodenal and splanchnic blood flow, increased vascular resistance, enhanced platelet aggregation,38–44 and reduced portal and mesenteric blood flow via inhibition of vasodilator peptides.45 Rossini and colleagues38 performed the first study evaluating somatostatin analogues for treatment of bleeding GIADs.
Effect of postoperative utilization of somatostatin on clinical outcome after definitive surgery for duodenal fistula
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