Regular ArticlesCYTOKINE IMBALANCE IN NON-IMMUNOLOGICAL CHRONIC DISEASE
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Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis
2014, Journal of NeuroimmunologyCitation Excerpt :Cerebral ischemia triggers an inflammatory response characterized by the up-regulation of inflammatory cytokines within the brain, as well as in peripheral blood (del Zoppo et al., 2000). Although the over expression of interleukin-6 (IL-6) by astrocytes and microglia may have a dual role in acute ischemia, with both neurotoxic and neuroprotective roles attributed to this cytokine (Van Wagoner and Benveniste, 1999; Muller, 2002), blood levels of IL-6 have been repeatedly associated with poor outcome (Smith et al., 2004; Waje-Andreassen et al., 2005) after stroke. The reason for this association, however, is not fully understood.
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Correspondence to: Brigitte Müller, Deutsches RheumaForschungs-Zentrum, Schumannstr. 21/22, 10117 Berlin, Germany. Tel: +49 30 28460 761; Fax: +49 30 28460 604; E-mail: [email protected]