Regular ArticleVitamin D3 and Its Synthetic Analogs Inhibit the Spontaneous in Vitro Immunoglobulin Production by SLE-Derived PBMC
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2018, Seminars in Arthritis and RheumatismCitation Excerpt :When we restricted the analysis to APS patients, we found an association between aB2GPI and a higher number of positive antibodies and vitD insufficiency. This finding keeps in line with in vitro studies showing that active vitD reduced antibody secretion and autoantibody production in SLE patients [26]. Regarding APS patients, only Paupitz et al. [13] evaluated the autoantibodies profile and the vitD status.
Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency
2018, Advances in Medical SciencesCitation Excerpt :Another study, conducted among healthy elderly people (1470 subjects), aged over 60, showed that in the summer the IgG concentration rises along with the 25(OH)D concentration [40]. It is thought that vitamin D, by acting on the mobilised B lymphocyte, causes, inter alia, a reduction in the concentration of excessively produced immunoglobulins, which happens in autoimmune diseases [38]. An inhibitory effect of 1.25(OH)2D on E immunoglobulin production by B lymphocytes is also observed [41].
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2018, Dubois' Lupus Erythematosus and Related SyndromesRegulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity
2017, Endocrinology and Metabolism Clinics of North AmericaCitation Excerpt :In addition, 1,25(OH)2D3 has direct inhibiting effects on B-cell proliferation and memory B-cell formation, and induces apoptosis of the activated B cells from patients with SLE. Moreover, active vitamin D reduces the polyclonal and anti–double-stranded DNA Ig production by the B cells, resulting in reduced autoantibody titers.57,216 During active disease, an increase in Th17 cells is observed in patients with SLE.217
Vitamin D3 mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in SLE
2024, Experimental DermatologyInvolvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19
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Jim Klinenberg: 6/26/1934–12/28/1999.
- 1
To whom correspondence and reprint requests should be addressed at Cedars-Sinai Medical Center D-5073, 8700 Beverly Blvd., Los Angeles CA 90048. E-mail: [email protected].
- 2
Present address: Humboldt University, Department of Medicine (Charite), Division of Hematology/Oncology, Berlin, Germany.