T-Lymphocyte subsets

Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Jaxaira Maggi, Montserrat Carrascal, Lilian Soto, Oscar Neira, María C Cuéllar, Octavio Aravena, Eddie A James, Joaquin Abian, Dolores Jaraquemada, Diego Catalan, Juan C Aguillón

Annals of the Rheumatic Diseases Apr 2022, annrheumdis-2021-220371; DOI: 10.1136/annrheumdis-2021-220371
Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity
Zhenhuan Zhao, Bihua Xu, Shuang Wang, Mianjing Zhou, Yuefang Huang, Chaohuan Guo, Mengyuan Li, Jijun Zhao, Sun-Sang J Sung, Felicia Gaskin, Niansheng Yang, Shu Man Fu

Annals of the Rheumatic Diseases Apr 2022, annrheumdis-2021-221985; DOI: 10.1136/annrheumdis-2021-221985
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor
Changrong Ge, Sylvia Weisse, Bingze Xu, Doreen Dobritzsch, Johan Viljanen, Jan Kihlberg, Nhu-Nguyen Do, Nadine Schneider, Harald Lanig, Rikard Holmdahl, Harald Burkhardt

Annals of the Rheumatic Diseases Apr 2022, 81 (4) 480-489; DOI: 10.1136/annrheumdis-2021-220500
Rheumatoid arthritis disease activity assessed by patient-reported outcomes and flow cytometry before and after an additional dose of COVID-19 vaccine
Sara K Tedeschi, Jacklyn Stratton, Jack Elias Ellrodt, Mary Grace Whelan, Keigo Hayashi, Kazuki Yoshida, Lin Chen, Ifeoluwakiisi Adejoorin, Kathryne Elizabeth Marks, A. Helena Jonsson, Deepak A Rao, Daniel H Solomon

Annals of the Rheumatic Diseases Feb 2022, annrheumdis-2022-222232; DOI: 10.1136/annrheumdis-2022-222232
Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis
Achilleas Floudas, Nuno Neto, Carl Orr, Mary Canavan, Phil Gallagher, Conor Hurson, Michael G Monaghan, Sunil Nagpar, Ronan H Mullan, Douglas J Veale, Ursula Fearon

Annals of the Rheumatic Diseases Feb 2022, 81 (2) 193-205; DOI: 10.1136/annrheumdis-2021-220458
Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages
Linyu Geng, Jian Zhao, Yun Deng, Ivan Molano, Xue Xu, Lingxiao Xu, Phillip Ruiz, Quanzhen Li, Xuebing Feng, Miaojia Zhang, Wenfeng Tan, Diane L Kamen, Sang-Cheol Bae, Gary S Gilkeson, Lingyun Sun, Betty P Tsao

Annals of the Rheumatic Diseases Feb 2022, 81 (2) 255-267; DOI: 10.1136/annrheumdis-2021-220793
Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis
Ignatius Ryan Adriawan, Faranaz Atschekzei, Oliver Dittrich-Breiholz, Panagiotis Garantziotis, Stefanie Hirsch, Linus Maximillian Risser, Maike Kosanke, Reinhold Ernst Schmidt, Torsten Witte, Georgios Sogkas

Annals of the Rheumatic Diseases Jan 2022, 81 (1) 124-131; DOI: 10.1136/annrheumdis-2021-220955
B cell depletion impairs vaccination-induced CD8⁺ T cell responses in a type I interferon-dependent manner
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzmán, Gerd Sutter, Reinhold E Schmidt, Torsten Witte, Ulrich Kalinke

Annals of the Rheumatic Diseases Dec 2021, 80 (12) 1537-1544; DOI: 10.1136/annrheumdis-2021-220435
Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis
Alyxzandria M Gaydosik, Tracy Tabib, Robyn Domsic, Dinesh Khanna, Robert Lafyatis, Patrizia Fuschiotti

Annals of the Rheumatic Diseases Nov 2021, 80 (11) 1453-1460; DOI: 10.1136/annrheumdis-2021-220209
Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis
Naoko Okiyama, Yuki Ichimura, Miwako Shobo, Ryota Tanaka, Noriko Kubota, Akimasa Saito, Yosuke Ishitsuka, Rei Watanabe, Yasuhiro Fujisawa, Yoshiyuki Nakamura, Akihiro Murakami, Hisako Kayama, Kiyoshi Takeda, Manabu Fujimoto

Annals of the Rheumatic Diseases Sep 2021, 80 (9) 1201-1208; DOI: 10.1136/annrheumdis-2020-218661

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