T Cells

A circulating reservoir of pathogenic-like CD4⁺ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment
Roberto Spreafico, Maura Rossetti, Jorg van Loosdregt, Carol A Wallace, Margherita Massa, Silvia Magni-Manzoni, Marco Gattorno, Alberto Martini, Daniel J Lovell, Salvatore Albani

Annals of the Rheumatic Diseases Feb 2016, 75 (2) 459-465; DOI: 10.1136/annrheumdis-2014-206226
IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis
Amy E Anderson, Arthur G Pratt, Mamdouh A K Sedhom, John Paul Doran, Christine Routledge, Ben Hargreaves, Philip M Brown, Kim-Anh Lê Cao, John D Isaacs, Ranjeny Thomas

Annals of the Rheumatic Diseases Feb 2016, 75 (2) 466-473; DOI: 10.1136/annrheumdis-2014-205850
CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis
T H C M Reinards, H M Albers, D M C Brinkman, S S M Kamphuis, M A J van Rossum, H J Girschick, C Wouters, E P A H Hoppenreijs, R K Saurenmann, A Hinks, J A Ellis, E Bakker, W Verduijn, P Slagboom, T W J Huizinga, R E M Toes, J J Houwing-Duistermaat, R ten Cate, M W Schilham

Annals of the Rheumatic Diseases Dec 2015, 74 (12) 2193-2198; DOI: 10.1136/annrheumdis-2013-205138
Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17
S Lightman, S R J Taylor, C Bunce, H Longhurst, W Lynn, R Moots, M Stanford, O Tomkins-Netzer, D Yang, V L Calder, D O Haskard

Annals of the Rheumatic Diseases Jun 2015, 74 (6) 1138-1144; DOI: 10.1136/annrheumdis-2014-205571
Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis
Qihui Zhou, Sonja Haupt, Johannes T Kreuzer, Ariane Hammitzsch, Fabian Proft, Carla Neumann, Jan Leipe, Matthias Witt, Hendrik Schulze-Koops, Alla Skapenko

Annals of the Rheumatic Diseases Jun 2015, 74 (6) 1265-1274; DOI: 10.1136/annrheumdis-2013-204377
Th17 cells play a critical role in the development of experimental Sjögren's syndrome
Xiang Lin, Ke Rui, Jun Deng, Jie Tian, Xiaohui Wang, Shengjun Wang, King-Hung Ko, Zhijun Jiao, Vera Sau-Fong Chan, Chak Sing Lau, Xuetao Cao, Liwei Lu

Annals of the Rheumatic Diseases Jun 2015, 74 (6) 1302-1310; DOI: 10.1136/annrheumdis-2013-204584
Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
Jens Y Humrich, Caroline von Spee-Mayer, Elise Siegert, Tobias Alexander, Falk Hiepe, Andreas Radbruch, Gerd-Rüdiger Burmester, Gabriela Riemekasten

Annals of the Rheumatic Diseases Apr 2015, 74 (4) 791-792; DOI: 10.1136/annrheumdis-2014-206506
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming
Khader Valli Rupanagudi, Onkar P Kulkarni, Julia Lichtnekert, Murthy Narayana Darisipudi, Shrikant R Mulay, Brigitte Schott, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders

Annals of the Rheumatic Diseases Feb 2015, 74 (2) 452-463; DOI: 10.1136/annrheumdis-2013-203717
Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis
M I P Ramos, O N Karpus, P Broekstra, S Aarrass, S E Jacobsen, P P Tak, M C Lebre

Annals of the Rheumatic Diseases Jan 2015, 74 (1) 211-219; DOI: 10.1136/annrheumdis-2013-203371
B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis
Laetitia Rapetti, Konstantia-Maria Chavele, Catherine M Evans, Michael R Ehrenstein

Annals of the Rheumatic Diseases Jan 2015, 74 (1) 294-302; DOI: 10.1136/annrheumdis-2013-204049

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