T Cells

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
Caroline von Spee-Mayer, Elise Siegert, Dimas Abdirama, Angelika Rose, Anika Klaus, Tobias Alexander, Philipp Enghard, Birgit Sawitzki, Falk Hiepe, Andreas Radbruch, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Jens Y Humrich

Annals of the Rheumatic Diseases Jul 2016, 75 (7) 1407-1415; DOI: 10.1136/annrheumdis-2015-207776
RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation
Lynett Danks, Noriko Komatsu, Matteo M Guerrini, Shinichiro Sawa, Marietta Armaka, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi

Annals of the Rheumatic Diseases Jun 2016, 75 (6) 1187-1195; DOI: 10.1136/annrheumdis-2014-207137
Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis
G Reynolds, J R Gibbon, A G Pratt, M J Wood, D Coady, G Raftery, A R Lorenzi, A Gray, A Filer, C D Buckley, M A Haniffa, J D Isaacs, C M U Hilkens

Annals of the Rheumatic Diseases May 2016, 75 (5) 899-907; DOI: 10.1136/annrheumdis-2014-206578
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
Liye Chen, Anna Ridley, Ariane Hammitzsch, Mohammad Hussein Al-Mossawi, Helen Bunting, Dimitris Georgiadis, Antoni Chan, Simon Kollnberger, Paul Bowness

Annals of the Rheumatic Diseases May 2016, 75 (5) 916-923; DOI: 10.1136/annrheumdis-2014-206996
Overlap between differentially methylated DNA regions in blood B lymphocytes and genetic at-risk loci in primary Sjögren's syndrome
Corinne Miceli-Richard, Shu-Fang Wang-Renault, Saida Boudaoud, Florence Busato, Céline Lallemand, Kevin Bethune, Rakiba Belkhir, Gaétane Nocturne, Xavier Mariette, Jörg Tost

Annals of the Rheumatic Diseases May 2016, 75 (5) 933-940; DOI: 10.1136/annrheumdis-2014-206998
Premature senescence of T-cell subsets in axial spondyloarthritis
Johannes Fessler, Andrea Raicht, Rusmir Husic, Anja Ficjan, Christina Duftner, Wolfgang Schwinger, Christian Dejaco, Michael Schirmer

Annals of the Rheumatic Diseases Apr 2016, 75 (4) 748-754; DOI: 10.1136/annrheumdis-2014-206119
A circulating reservoir of pathogenic-like CD4⁺ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment
Roberto Spreafico, Maura Rossetti, Jorg van Loosdregt, Carol A Wallace, Margherita Massa, Silvia Magni-Manzoni, Marco Gattorno, Alberto Martini, Daniel J Lovell, Salvatore Albani

Annals of the Rheumatic Diseases Feb 2016, 75 (2) 459-465; DOI: 10.1136/annrheumdis-2014-206226
IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis
Amy E Anderson, Arthur G Pratt, Mamdouh A K Sedhom, John Paul Doran, Christine Routledge, Ben Hargreaves, Philip M Brown, Kim-Anh Lê Cao, John D Isaacs, Ranjeny Thomas

Annals of the Rheumatic Diseases Feb 2016, 75 (2) 466-473; DOI: 10.1136/annrheumdis-2014-205850
CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis
T H C M Reinards, H M Albers, D M C Brinkman, S S M Kamphuis, M A J van Rossum, H J Girschick, C Wouters, E P A H Hoppenreijs, R K Saurenmann, A Hinks, J A Ellis, E Bakker, W Verduijn, P Slagboom, T W J Huizinga, R E M Toes, J J Houwing-Duistermaat, R ten Cate, M W Schilham

Annals of the Rheumatic Diseases Dec 2015, 74 (12) 2193-2198; DOI: 10.1136/annrheumdis-2013-205138
Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17
S Lightman, S R J Taylor, C Bunce, H Longhurst, W Lynn, R Moots, M Stanford, O Tomkins-Netzer, D Yang, V L Calder, D O Haskard

Annals of the Rheumatic Diseases Jun 2015, 74 (6) 1138-1144; DOI: 10.1136/annrheumdis-2014-205571

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