Systemic Sclerosis

Haemodynamic phenotypes and survival in patients with systemic sclerosis: the impact of the new definition of pulmonary arterial hypertension
Panagiota Xanthouli, Suzana Jordan, Nicklas Milde, Alberto Marra, Norbert Blank, Benjamin Egenlauf, Matthias Gorenflo, Satenik Harutyunova, Hanns-Martin Lorenz, Christian Nagel, Vivienne Theobald, Mona Lichtblau, Charlotte Berlier, Silvia Ulrich, Ekkehard Grünig, Nicola Benjamin, Oliver Distler

Annals of the Rheumatic Diseases Dec 2019, annrheumdis-2019-216476; DOI: 10.1136/annrheumdis-2019-216476
Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile
Brian Skaug, Dinesh Khanna, William R Swindell, Monique E Hinchcliff, Tracy M Frech, Virginia D Steen, Faye N Hant, Jessica K Gordon, Ami A Shah, Lisha Zhu, W Jim Zheng, Jeffrey L Browning, Alexander M S Barron, Minghua Wu, Sudha Visvanathan, Patrick Baum, Jennifer M Franks, Michael L Whitfield, Victoria K Shanmugam, Robyn T Domsic, Flavia V Castelino, Elana J Bernstein, Nancy Wareing, Marka A Lyons, Jun Ying, Julio Charles, Maureen D Mayes, Shervin Assassi

Annals of the Rheumatic Diseases Nov 2019, annrheumdis-2019-215894; DOI: 10.1136/annrheumdis-2019-215894
Revised European Scleroderma Trials and Research Group Activity Index is the best predictor of short-term severity accrual
Serena Fasano, Antonella Riccardi, Valentina Messiniti, Paola Caramaschi, Edoardo Rosato, Britta Maurer, Vanessa Smith, Elise Siegert, Ellen De Langhe, Valeria Riccieri, Paolo Airó, Carina Mihai, Jerome Avouac, Elisabetta Zanatta, Ulrich A Walker, Florenzo Iannone, Paloma García De la Peña Lefebvre, Jörg H W Distler, Alessandra Vacca, Oliver Distler, Otylia Kowal-Bielecka, Yannick Allanore, Gabriele Valentini

Annals of the Rheumatic Diseases Dec 2019, 78 (12) 1681-1685; DOI: 10.1136/annrheumdis-2019-215787
Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs
Alexandru-Emil Matei, Chih-Wei Chen, Lisa Kiesewetter, Andrea-Hermina Györfi, Yi-Nan Li, Thuong Trinh-Minh, Xiaohan Xu, Cuong Tran Manh, Toin van Kuppevelt, Jan Hansmann, Astrid Jüngel, Georg Schett, Florian Groeber-Becker, Jörg H W Distler

Annals of the Rheumatic Diseases Dec 2019, 78 (12) 1686-1692; DOI: 10.1136/annrheumdis-2019-216108
Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019
Kevin L Winthrop, Michael E Weinblatt, Joan Bathon, Gerd R Burmester, Philip J Mease, Leslie Crofford, Vivian Bykerk, Maxime Dougados, James Todd Rosenbaum, Xavier Mariette, Joachim Sieper, Fritz Melchers, Bruce N Cronstein, Ferry C Breedveld, Joachim Kalden, Josef S Smolen, Daniel Furst

Annals of the Rheumatic Diseases Oct 2019, annrheumdis-2019-216151; DOI: 10.1136/annrheumdis-2019-216151
Possible adaptations of vascularised human skin equivalents to include rare cell populations and study fibroblast heterogeneity. Response to: ‘In search for the ideal anatomical composition of vascularised human skin equivalents for systemic sclerosis translational research: should we recruit the telocytes?’ by Manetti and Matucci-Cerinic
Alexandru Emil Matei, Jörg H W Distler

Annals of the Rheumatic Diseases Oct 2019, annrheumdis-2019-216393; DOI: 10.1136/annrheumdis-2019-216393
Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis
Minghua Wu, Brian Skaug, Xiongjie Bi, Tingting Mills, Gloria Salazar, Xiaodong Zhou, John Reveille, Sandeep K Agarwal, Michael R Blackburn, Maureen D Mayes, Shervin Assassi

Annals of the Rheumatic Diseases Nov 2019, 78 (11) 1583-1591; DOI: 10.1136/annrheumdis-2019-215208
Effectiveness and safety of tocilizumab for the treatment of refractory systemic sclerosis associated interstitial lung disease: a case series
Javier Narváez, Judit LLuch, Juan José Alegre Sancho, Maria Molina-Molina, Joan Miquel Nolla, Ivan Castellví

Annals of the Rheumatic Diseases Nov 2019, 78 (11) e123; DOI: 10.1136/annrheumdis-2018-214449
Response to: ‘Effectiveness and safety of tocilizumab for the treatment of refractory systemic sclerosis associated interstitial lung disease: a case series’ by Narváez
Dinesh Khanna, Angelika Jahreis, Celia J F Lin

Annals of the Rheumatic Diseases Nov 2019, 78 (11) e124; DOI: 10.1136/annrheumdis-2018-214477
Response to: ‘Will SPAR be useful in the usual patients with scleroderma?’ by Chattopadhyay et al
Wanlong Wu, Suzana Jordan, Oliver Distler

Annals of the Rheumatic Diseases Nov 2019, 78 (11) e126; DOI: 10.1136/annrheumdis-2018-214270

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