Pharmacokinetics

In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption
Yoshinobu Matsuura, Junichi Kikuta, Yuika Kishi, Tetsuo Hasegawa, Daisuke Okuzaki, Toru Hirano, Masafumi Minoshima, Kazuya Kikuchi, Atsushi Kumanogoh, Masaru Ishii

Annals of the Rheumatic Diseases Aug 2018, 77 (8) 1219-1225; DOI: 10.1136/annrheumdis-2017-212880
Comment on l’Ami et al titled ’Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial'
Alfons A den Broeder, Bart J F van den Bemt

Annals of the Rheumatic Diseases Nov 2017, annrheumdis-2017-212579; DOI: 10.1136/annrheumdis-2017-212579
Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles
Chris Chamberlain, Peter J Colman, Ann M Ranger, Linda C Burkly, Geoffrey I Johnston, Christian Otoul, Christian Stach, Miren Zamacona, Thomas Dörner, Murray Urowitz, Falk Hiepe

Annals of the Rheumatic Diseases Nov 2017, 76 (11) 1837-1844; DOI: 10.1136/annrheumdis-2017-211388
A randomised, single-blind, single-dose, three-arm, parallel-group study in healthy subjects to demonstrate pharmacokinetic equivalence of ABP 501 and adalimumab
Primal Kaur, Vincent Chow, Nan Zhang, Michael Moxness, Arunan Kaliyaperumal, Richard Markus

Annals of the Rheumatic Diseases Mar 2017, 76 (3) 526-533; DOI: 10.1136/annrheumdis-2015-208914
A multicentre randomised controlled trial to compare the pharmacokinetics, efficacy and safety of CT-P10 and innovator rituximab in patients with rheumatoid arthritis
Dae Hyun Yoo, Chang-Hee Suh, Seung Cheol Shim, Slawomir Jeka, Francisco Fidencio Cons-Molina, Pawel Hrycaj, Piotr Wiland, Eun Young Lee, Francisco G Medina-Rodriguez, Pavel Shesternya, Sebastiao Radominski, Marina Stanislav, Volodymyr Kovalenko, Dong Hyuk Sheen, Leysan Myasoutova, Mie Jin Lim, Jung-Yoon Choe, Sang Joon Lee, Sung Young Lee, Taek Sang Kwon, Won Park

Annals of the Rheumatic Diseases Mar 2017, 76 (3) 566-570; DOI: 10.1136/annrheumdis-2016-209540
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol
Fernando Perez-Ruiz, John S Sundy, Jeffrey N Miner, Matthew Cravets, Chris Storgard

Annals of the Rheumatic Diseases Jun 2016, 75 (6) 1074-1080; DOI: 10.1136/annrheumdis-2015-207919
Lower etanercept levels are associated with high disease activity in ankylosing spondylitis patients at 24 weeks of follow-up
E L Kneepkens, C L M Krieckaert, D van der Kleij, M T Nurmohamed, I E van der Horst-Bruinsma, T Rispens, G J Wolbink

Annals of the Rheumatic Diseases Oct 2015, 74 (10) 1825-1829; DOI: 10.1136/annrheumdis-2014-205213
Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis
D E A Greven, E S Cohen, D M Gerlag, J Campbell, J Woods, N Davis, A van Nieuwenhuijze, A Lewis, S Heasmen, M McCourt, D Corkill, A Dodd, J Elvin, G Statache, I P Wicks, I K Anderson, A Nash, M A Sleeman, P P Tak

Annals of the Rheumatic Diseases Oct 2015, 74 (10) 1924-1930; DOI: 10.1136/annrheumdis-2014-205234
Key findings towards optimising adalimumab treatment: the concentration–effect curve
Mieke F Pouw, Charlotte L Krieckaert, Michael T Nurmohamed, Desiree van der Kleij, Lucien Aarden, Theo Rispens, Gertjan Wolbink

Annals of the Rheumatic Diseases Mar 2015, 74 (3) 513-518; DOI: 10.1136/annrheumdis-2013-204172
Adalimumab trough concentrations in patients with rheumatoid arthritis and psoriatic arthritis treated with concomitant disease-modifying antirheumatic drugs
E H Vogelzang, M F Pouw, M Nurmohamed, E L Kneepkens, T Rispens, G J Wolbink, C L M Krieckaert

Annals of the Rheumatic Diseases Feb 2015, 74 (2) 474-475; DOI: 10.1136/annrheumdis-2014-206588

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