Methotrexate

Radiographic benefit and maintenance of clinical benefit with intravenous golimumab therapy in patients with active rheumatoid arthritis despite methotrexate therapy: results up to 1 year of the phase 3, randomised, multicentre, double blind, placebo controlled GO-FURTHER trial
Michael E Weinblatt, Rene Westhovens, Alan M Mendelsohn, Lilianne Kim, Kim Hung Lo, Shihong Sheng, Lenore Noonan, Jiandong Lu, Zhenhua Xu, Jocelyn Leu, Daniel Baker, Clifton O Bingham

Annals of the Rheumatic Diseases Dec 2014, 73 (12) 2152-2159; DOI: 10.1136/annrheumdis-2013-203742
The TRIFRA trial: efforts employed to minimise expectation bias
Qian-wen Lv, Wen Zhang, Qun Shi, Wen-jie Zheng, Peter E Lipsky, Xuan Zhang

Annals of the Rheumatic Diseases Nov 2014, 73 (11) e67; DOI: 10.1136/annrheumdis-2014-206197
Comment on: ‘Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial’ by Qian-wen et al
Robert B M Landewé, Désirée van der Heijde

Annals of the Rheumatic Diseases Oct 2014, 73 (10) e62; DOI: 10.1136/annrheumdis-2014-206124
TwHF versus methotrexate in the treatment of rheumatoid arthritis: response to Landewe's comment on the TRIFRA study
Qian-wen Lv, Tao Chen, Wen Zhang, Qun Shi, Wen-jie Zheng, Peter E Lipsky, Xuan Zhang

Annals of the Rheumatic Diseases Oct 2014, 73 (10) e63; DOI: 10.1136/annrheumdis-2014-206156
Is there a direct relationship between serum level of methotrexate and clinical efficacy and tolerability?
Roy Fleischmann, Yusuf Yazici

Annals of the Rheumatic Diseases Sep 2014, 73 (9) e54; DOI: 10.1136/annrheumdis-2014-205901
Response to: ‘Is there a direct relationship between serum level of methotrexate and clinical efficacy and tolerability?’ by Fleishman and Yazici
Michael H Schiff, Jonathan S Jaffe, Bruce Freundlich

Annals of the Rheumatic Diseases Sep 2014, 73 (9) e55; DOI: 10.1136/annrheumdis-2014-205938
Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of rheumatoid arthritis
Donald M Marcus

Annals of the Rheumatic Diseases Sep 2014, 73 (9) e56; DOI: 10.1136/annrheumdis-2014-205971
Response to D.M. Marcus's comment on the TRIFRA study (comparison of Tripterygium wilfordii Hook F vs methotrexate in the treatment of active rheumatoid arthritis)
Qian-wen Lv, Wen Zhang, Qun Shi, Wen-jie Zheng, Peter E Lipsky, Xuan Zhang

Annals of the Rheumatic Diseases Sep 2014, 73 (9) e57; DOI: 10.1136/annrheumdis-2014-205973
Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy
Josef S Smolen, Michael E Weinblatt, Shihong Sheng, Yanli Zhuang, Benjamin Hsu

Annals of the Rheumatic Diseases Sep 2014, 73 (9) 1616-1625; DOI: 10.1136/annrheumdis-2013-205137
Efficacy and safety of golimumab as add-on therapy to disease-modifying antirheumatic drugs: results of the GO-MORE study
Bernard Combe, Bhaskar Dasgupta, Ingrid Louw, Sarvajeet Pal, Jürgen Wollenhaupt, Cristiano A F Zerbini, Andre D Beaulieu, Hendrik Schulze-Koops, Patrick Durez, Ruji Yao, Nathan Vastesaeger, Haoling H Weng, on Behalf of the GO-MORE Investigators

Annals of the Rheumatic Diseases Aug 2014, 73 (8) 1477-1486; DOI: 10.1136/annrheumdis-2013-203229

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