Fibroblasts

METTL3-mediated m⁶A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression
Xiang Chen, Wang Gong, Xiaoyan Shao, Tianshu Shi, Lei Zhang, Jian Dong, Yong Shi, Siyu Shen, Jianghui Qin, Qing Jiang, Baosheng Guo

Annals of the Rheumatic Diseases Jan 2022, 81 (1) 85-97; DOI: 10.1136/annrheumdis-2021-221091
Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis
Vanessa Waltereit-Kracke, Corinna Wehmeyer, Denise Beckmann, Eugenie Werbenko, Julia Reinhardt, Fabienne Geers, Mike Dienstbier, Michelle Fennen, Johanna Intemann, Peter Paruzel, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar

Annals of the Rheumatic Diseases Apr 2022, annrheumdis-2021-221409; DOI: 10.1136/annrheumdis-2021-221409
Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over time
Brian Skaug, Marka A Lyons, William R Swindell, Gloria A Salazar, Minghua Wu, Tuan M Tran, Julio Charles, Connor P Vershel, Maureen D Mayes, Shervin Assassi

Annals of the Rheumatic Diseases Apr 2022, 81 (4) 516-523; DOI: 10.1136/annrheumdis-2021-221352
Epigenetic profiling of twins identify repression of KLF4 as a novel pathomechanism in systemic sclerosis
Jörg H W Distler, Steven O'Reilly

Annals of the Rheumatic Diseases Feb 2022, 81 (2) 151-152; DOI: 10.1136/annrheumdis-2021-221605
Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
Rebecca A Symons, Fabio Colella, Fraser L Collins, Alexandra J Rafipay, Karolina Kania, Jessica J McClure, Nathan White, Iain Cunningham, Sadaf Ashraf, Elizabeth Hay, Kevin S Mackenzie, Kenneth A Howard, Anna H K Riemen, Antonio Manzo, Susan M Clark, Anke J Roelofs, Cosimo De Bari

Annals of the Rheumatic Diseases Feb 2022, 81 (2) 214-224; DOI: 10.1136/annrheumdis-2021-220875
Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis
Maya Malaab, Ludivine Renaud, Naoko Takamura, Kip D Zimmerman, Willian A da Silveira, Paula S Ramos, Sandra Haddad, Marc Peters-Golden, Loka R Penke, Bethany Wolf, Gary Hardiman, Carl D Langefeld, Thomas A Medsger, Carol A Feghali-Bostwick

Annals of the Rheumatic Diseases Feb 2022, 81 (2) 268-277; DOI: 10.1136/annrheumdis-2021-221050
Integrative analysis of lung molecular signatures reveals key drivers of systemic sclerosis-associated interstitial lung disease
Seung Min Jung, Kyung-Su Park, Ki-Jo Kim

Annals of the Rheumatic Diseases Jan 2022, 81 (1) 108-116; DOI: 10.1136/annrheumdis-2021-220493
TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis
Paôline Laurent, Benoit Allard, Pauline Manicki, Valérie Jolivel, Emeline Levionnois, Mohamed Jeljeli, Pauline Henrot, Julien Izotte, Damien Leleu, Alexis Groppi, Julien Seneschal, Joel Constans, Carlo Chizzolini, Christophe Richez, Pierre Duffau, Estibaliz Lazaro, Edouard Forcade, Thierry Schaeverbeke, Thomas Pradeu, Frédéric Batteux, Patrick Blanco, Cécile Contin-Bordes, Marie-Elise Truchetet

Annals of the Rheumatic Diseases Dec 2021, 80 (12) 1594-1603; DOI: 10.1136/annrheumdis-2020-219748
In search for the ideal anatomical composition of vascularised human skin equivalents for systemic sclerosis translational research: should we recruit the telocytes?
Mirko Manetti, Marco Matucci-Cerinic

Annals of the Rheumatic Diseases Sep 2021, 80 (9) e149; DOI: 10.1136/annrheumdis-2019-216371
X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc)
Christina Bergmann, Ludwig Hallenberger, Sara Chenguiti Fakhouri, Benita Merlevede, Amelie Brandt, Clara Dees, Honglin Zhu, Ariella Zehender, Xiang Zhou, Annemarie Schwab, Chih-Wei Chen, Andrea Hermina Györfi, Alexandru Emil Matei, Debomita Chakraborty, Thuong Trinh-Minh, Simon Rauber, Roland Coras, Aline Bozec, Alexander Kreuter, Mirjana Ziemer, Georg Schett, Jörg H W Distler

Annals of the Rheumatic Diseases Aug 2021, 80 (8) 1048-1056; DOI: 10.1136/annrheumdis-2020-219822

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