Relevant scan properties of [99mTc]Tc-HDP SPECT/CT or PET/CT versus MRI for initial evaluation of adult CNO
| Feature | [99mTc]Tc-HDP SPECT/CT or PET/CT | MRI |
| Detection of new bone formation | Very good | Fair |
| Detection of bone inflammation | Fair (visualised through bone turnover) | Good |
| Detection of soft tissue inflammation | Poor | Good |
| Ease of performance | Good | Fair |
| Ease of interpretation | Fair | Poor |
| Ionising radiation | Considerable | None |
| Contraindications | Few | Metal, claustrophobia |
CNO, chronic non-bacterial osteitis; [99mTc]Tc-HDP SPECT/CT, technetium-labelled hydroxymethylene diphosphonate single positron emission CT; PET, positron emission tomography.