Table 2

Conventional semen parameters and sperm morphology

MTX-naïve
Pre-exposure (n=20)
MTX-naïve
Post-exposure (n=18)
Healthy controls (n=25)MTX chronic* (n=5)P value
Conventional semen parameters
Sperm concentration x106/mL, median (IQR)57.0 (35.0–90.5)54.0 (41.0–82.0)60.0 (37.0–111.0)37.0 (32.0–59.9)NS
Progressive motility* %,
mean (95% CI)
63.2 (55.4 to 70.9)60.1 (49.5 to 70.6)56.9 (51.1 to 62.8)50.4 (34.8 to 65.9)NS
Semen volume mL, median (IQR)2.4 (1.6–3.2)3.0 (1.5–3.2)3.0 (2.0–4.0)2.0 (1.6–2.4)NS
Sperm morphology evaluation
Normal morphology %, mean (95% CI)6.4 (4.5 to 8.3)7.1 (5.6 to 8.4)6.3 (4.7 to 7.9)5.9 (2.6 to 9.1)NS
Teratozoospermia index, mean (95% CI)1.2 (1.2 to 1.3)1.3 (1.2 to 1.4)1.2 (1.2 to 1.3)1.2 (1.1 to 1.4)NS
Excess residual cytoplasm, median (IQR)2.0 (0.7–4.3)2.0 (1.0–4.5)2.0 (1.0–4.0)2.0 (1.0–4.0)NS
Abnormalities in head (%), mean (95% CI)92.8 (90.8 to 94.7)93.0 (91.2 to 94.6)92.7 (91.0 to 94.3)92.3 (88.0 to 96.5)NS
Abnormalities in middle piece (%), mean (95% CI)19.2 (14.2 to 24.1)24.5 (18.6 to 30.2)19.9 (15.3 to 24.5)22.9 (5.7 to 40.0)NS
Abnormalities in tail (%), mean (95% CI)7.1 (3.8 to 10.5)7.3 (3.7 to 11.1)6.6 (3.9 to 9.3)4.6 (1.4 to 7.7)NS
  • *Presented only for descriptive purposes, no statistical analyses were conducted.

  • MTX, methotrexate.