Table 1:

Interaction effects of severe pain (≥70 points) and inflammation with IA glucocorticoid for primary outcome of pain severity

	No. of studies	No. of participants	Adjusted mean reduction (β) (95%CI)	P	Cochran’s Q	I² (%)	Tau²
Interaction effect of severe pain with IA glucocorticoid^#
IA glucocorticoid versus placebo
Short-term	6	345 270 160	-5.98 (-18.28; 6.31)	0.266	4.47	0	0
Mid-term	5		-6.90 (-10.91; -2.90)	0.009	0.17	0	0
Long term	3		-2.84 (-62.69; 57.01)	0.857	2.88	30.5	0
IA glucocorticoid versus hyaluronic acid
Short-term	3	513	7.50 (-56.58; 71.57)	0.665	9.41	78.8	508.88
Mid-term	3	476	6.90 (-3.39; 17.20)	0.102	0.39	0	0
Long term	2	456	8.42 (-28.03; 44.86)	0.209	0.27	0	0
Interaction effect of inflammation with IA glucocorticoid*
IA glucocorticoid versus placebo
Short-term	5	296	-15.01 (-51.23; 21.21)	0.314	21.83	81.7	688.97
Mid-term	4	230	-5.96 (-35.81; 23.91)	0.571	5.95	49.6	172.64
Long term	2	126	-7.43 (-125.49; 110.63)	0.571	0.64	0	0
IA glucocorticoid versus hyaluronic acid
Short-term	2	360	-10.82 (-20.30; -1.33)	0.044	0.02	0	0
Mid-term	2	334	-9.22 (-70.10; 51.662)	0.305	0.62	0	0