Table 2

Comparison of different logistic regression models for response to TNFi, comparing grouped responders (moderate and good) and non-responders at 3-month follow-up, dichotomised based using high (75th) and low (25th) concentrations of MRP8/14 or CRP

	Responses categories calculated using:
	4-component DAS28				3-component DAS28				2-component DAS28
Model	Cases	OR (95% Cl)	Model fit (pseudo R²)	P value	Cases	OR (95% Cl)	Model fit (pseudo R²)	P value	Cases	OR (95% Cl)	Model fit (pseudo R²)	P value
Low vs high MRP8/14 (µg/mL)	218	1.22 (0.62 to 2.38)	0.0015	0.564	241	1.92 (1.04 to 3.54)	0.017	0.037	241	2.03 (1.09 to 3.78)	0.020	0.025
Low vs high MRP8/14 adjusted for pre-treatment CRP	218	1.10 (0.53 to 2.30)	0.0033	0.795	241	1.53 (0.78 to 2.98)	0.026	0.21	241	1.60 (0.82 to 3.15)	0.030	0.171
Low vs high CRP only (mg/L)	215	1.64 (0.78 to 3.4)	0.0092	0.188	234	3.79 (1.81 to 7.93)	0.062	<0.001	234	3.58 (1.74 to 7.35)	0.058	<0.001
Low vs high CRP adjusted for pre-treatment MRP8/14	215	1.79 (0.79 to 4.06)	0.011	0.163	234	4.11 (1.83 to 9.25)	0.063	0.001	234	3.73 (1.70 to 8.19)	0.059	0.001

Response categorises were calculated using 4 components, 3 components or 2 components.
CRP, C reactive protein; DAS28, disease activity scores in 28-joints; TNFi, tumour necrosis factor inhibitor.