Association of the four EHOA variants with other osteoarthritis in the GO consortium meta-analysis
| Finger OA (N=10 804 cases/255 814 controls) | Thumb OA (N=10 536 cases/236 919 controls) | Hip OA (N=36 520 cases/317 590 controls) | Knee OA (N=63 498 cases/335 777 controls) | Spine OA (N=28 731 cases/307 798 controls) | |||||||
| Variant (allele) | Chr:position | OR | P value | OR | P value | OR | P value | OR | P value | OR | P value |
| rs17013495(T) | chr4:87 885 460 | 1.08 | 2.3E-05* | 1.05 | 7.9E-03* | 0.99 | 0.16 | 1.00 | 0.58 | 1.01 | 0.32 |
| rs11243284(C) | chr6:8 945 086 | 1.10 | 1.3E-06* | 1.00 | 0.85 | 1.00 | 0.84 | 1.00 | 0.59 | 0.99 | 0.25 |
| rs1800801(T) | chr12:14 885 854 | 1.16 | 8.6E-16* | 1.06 | 2.5E-04* | 0.97 | 5.5E-03 | 0.98 | 2.3E-03* | 1.01 | 0.27 |
| rs11631127(C) | chr15:57 977 811 | 1.09 | 3.7E-07* | 1.10 | 1.3E-08* | 1.02 | 0.079 | 0.97 | 1.3E-06* | 1.00 | 0.64 |
Results are shown for OA subsets phenotypes in the Genetics of Osteoarthritis Consortium meta-analysis.12 Chr is chromosome, Pos is the position in build GRCh38.
*Denotes significant associations after correction for multiple testing.
EHOA, erosive hand osteoarthritis; GO, genetics of osteoarthritis; OA, osteoarthritis.