The top 10 SNPs associated with higher final mSASSS score (n=442*†)
SNP | Chr:Position | Beta | Gene | Function | P value |
rs191573523 | 15:33 922 208 | 1.127 | RYR3 | Exonic | 1.00×10−6 |
rs7518201 | 1:203 773 096 | −0.149 | ZC3H11A | Intronic | 1.00×10−5 |
rs76789191 | 3:55 614 320 | 0.580 | ERC2 | Intronic | 1.21×10−5 |
rs117416665 | 2:44 606 325 | 0.611 | CAMKMT | Intronic | 2.36×10−5 |
rs139358058 | 15:49 888 627 | 0.976 | FAM227B | Intronic | 2.78×10−5 |
rs7502336 | 17:78 281 770 | −0.160 | RNF213 | Intronic | 2.78×10−5 |
rs144589250 | 9:140 218 962 | 0.438 | EXD3 | Intronic | 3.17×10−5 |
rs16915331 | 9:101 135 201 | 0.897 | GABBR2 | Intronic | 3.28×10−5 |
rs11686946 | 2:128 394 955 | 0.182 | MYO7B | Exonic | 4.08×10−5 |
rs76838622 | 1:183 839 856 | 0.727 | RGL1 | Intronic | 4.36×10−5 |
*Smoking data were available for 442 patients.
†Log(mSASSS+1) value was used.
Chr, chromosome; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score; SNP, single nucleotide polymorphism.