Two-sample MR results for causality for gut microbiome influencing RA
| Method | nSNPs | OR (95% CI) | P value | Cochrane Q statistic | Heterogeneity p value | nSNPs* | OR (95% CI) * | P value* | Cochrane Q statistic* | Heterogeneity p value* |
| IVW | 37 | 0.98 (0.97–1.00) | 0.024 | 45.42 | 0.135 | 35 | 0.99 (0.97–1.01) | 0.175 | 37.96 | 0.294 |
| Weighted median | 37 | 0.99 (0.96–1.01) | 0.186 | NA | NA | 35 | 0.99 (0.97–1.01) | 0.382 | NA | NA |
| Weighted mode | 37 | 0.99 (0.96–1.02) | 0.542 | NA | NA | 35 | 0.99 (0.96–1.02) | 0.604 | NA | NA |
| MR-Egger | 37 | 1.00 (0.97–1.03) | 0.919 | 42.79 | 0.172 | 35 | 1.01 (0.99–1.04) | 0.313 | 33.05 | 0.465 |
*Sensitivity analysis without rs1172296 and rs986417.
IVW, inverse variance weighted; MR, Mendelian randomisation; NA, not applicable; nSNPs, number of single nucleotide polymorphisms; RA, rheumatoid arthritis.