Rates and LRs of RA patients achieving a good functional outcome (HAQ ≤0.5) and/or no radiographic progression (ΔmTSS) at 1 year, according to different remission criteria*
| Criteria fulfilled | HAQ ≤0.5 | No increase in mTSS | Combined variables | |||||||||
| No | Yes | LR+ (range) | LR− (range) | No | Yes | LR+ (range) | LR− (range) | No | Yes | LR+ (range) | LR− (range) | |
| Early RA | ||||||||||||
| Boolean1.0 | 43.3 | 85.9 | 6.19 (4.0–9.5) | 0.78 (0.7–0.8) | 65.6 | 78.5 | 1.76 (1.2–2.5) | 0.92 (0.9–1.0) | 31.7 | 67.5 | 3.54 (2.6–4.8) | 0.79 (0.7–0.8) |
| Boolean2.0 | 41.5 | 80.6 | 4.23 (3.1–5.7) | 0.72 (0.7–0.8) | 64.4 | 79.3 | 1.85 (1.4–2.4) | 0.87 (0.8–0.9) | 29.6 | 65.2 | 3.19 (2.5–4.1) | 0.72 (0.7–0.8) |
| BooleanX | 40.5 | 74.1 | 2.76 (2.3–3.3) | 0.58 (0.5–0.7) | 63.1 | 79.5 | 1.86 (1.4–2.4) | 0.82 (0.8–0.9) | 28.4 | 60.3 | 2.59 (2.1–3.2) | 0.67 (0.6–0.7) |
| SDAI | 41.4 | 83.3 | 3.88 (3.1–4.9) | 0.61 (0.5–0.7) | 64.6 | 79.2 | 1.83 (1.2–2.5) | 0.88 (0.8–0.9) | 29.7 | 66.7 | 3.41 (2.6–4.4) | 0.72 (0.7–0.8) |
| CDAI | 41.6 | 83.7 | 4.25 (3.4–5.4) | 0.60 (0.5–0.7) | 64.8 | 78.9 | 1.81 (1.3–2.5) | 0.89 (0.8–0.9) | 29.9 | 67 | 3.46 (2.7–4.5) | 0.73 (0.7–0.8) |
| Established RA | ||||||||||||
| Boolean1.0 | 29.2 | 72.5 | 5.86 (3.0–11.6) | 0.92 (0.9–1.0) | 32.6 | 37.5 | 1.23 (0.7–2.3) | 0.99 (0.9–1.0) | 12.1 | 22.5 | 2.02 (1.0–4.1) | 0.96 (0.9–1.0) |
| Boolean2.0 | 28.7 | 68.4 | 4.19 (2.5–7.0) | 0.85 (0.8–0.9) | 32.4 | 40.4 | 1.38 (0.8–2.3) | 0.98 (0.9–1.0) | 11.8 | 24.6 | 2.27 (1.3–4.0) | 0.93 (0.9–1.0) |
| BooleanX | 28.1 | 57.9 | 2.42 (1.6–3.8) | 0.86 (0.8–1.0) | 31.3 | 46.3 | 1.76 (1.2–2.6) | 0.93 (0.9–1.0) | 11.6 | 21.1 | 1.86 (1.2–2.9) | 0.91 (0.8–1.0) |
| SDAI | 29 | 71.7 | 4.84 (2.7–8.5) | 0.86 (0.8–0.9) | 32.6 | 37 | 1.2 (0.7–2.1) | 0.99 (0.9–1.0) | 12 | 23.9 | 2.19 (1.1–4.2) | 0.95 (0.9–1.0) |
| CDAI | 28.7 | 76.1 | 4.84 (2.7–8.5) | 0.86 (0.8–0.9) | 32.6 | 37 | 1.2 (0.7–2.1) | 0.99 (0.9–1.0) | 11.8 | 28.3 | 2.74 (1.5–5.1) | 0.93 (0.9–1.0) |
*Positive LR (LR+) and negative LRs (LR−) for reaching the respective outcome at 12 months if remission is achieved at 6 months are shown.
CDAI, Clinical Disease Activity Index; HAQ, Health Assessment Questionnaire; LRs, likelihood ratios; RA, rheumatoid arthritis; SDAI, Simplified Disease Activity Index; ΔmTSS, change in modified Sharp/van der Heijde score.