Findings of univariate and multivariate regression analyses of actual birth weight (kilogram) of RA patients (n=188) included in the PreCARA cohort
| Univariate linear regression analysis for birth weight (kg) | Multivariate linear regression analysis for birth weight (kg)* | |||||
| Coefficient | 95% CI | P value | Coefficient | 95% CI | P value | |
| Disease activity in third trimester (DAS28CRP) | – 0.20 | –0.31 to 0.085 | 0.001 | –0.091 | –0.19 to 0.0058 | 0.065 |
| Gestational age at delivery (weeks) | 0.17 | 0.14 to 0.21 | <0.001 | 0.18 | 0.15 to 0.22 | <0.001 |
| Maternal age (years) | – 0.013 | – 0.033 to 0.0074 | 0.21 | –0.023 | –0.040 to 0.0065 | 0.007 |
| Parity (nulliparity) | – 0.21 | – 0.36 to 0.047 | 0.011 | –0.13 | –0.26 to 0.0042 | 0.057 |
| Sex of the newborn (female) | 0.034 | – 0.13 to 0.20 | 0.67 | 0.081 | –0.053 to 0.21 | 0.24 |
| Type of conception (assisted reproduction) | – 0.075 | – 0.31 to 0.16 | 0.53 | –0.051 | –0.26 to 0.15 | 0.62 |
| Diabetes Mellitus (yes)† | 0.22 | – 0.084 to 0.53 | 0.15 | 0.37 | 0.12 to 0.63 | 0.004 |
| TNF inhibitor use during pregnancy (yes) | 0.17 | 0.014 to 0.33 | 0.033 | 0.20 | 0.066 to 0.34 | 0.004 |
| Prednisone use during pregnancy (yes) | – 0.064 | – 0.23 to 0.99 | 0.44 | – 0.99 | – 0.23 to 0.039 | 0.16 |
| Smoking during pregnancy (yes) | – 0.17 | – 0.62 to 0.29 | 0.47 | – 0.028 | – 0.41 to 0.35 | 0.89 |
*Corrected for all the other variables listed in this table.
†Combined variable of both preexisting diabetes mellitus and gestational diabetes mellitus.
DAS28CRP, Disease Activity Score in 28 joints C reactive protein; preCARA, Preconception Counseling in Active RA; RA, rheumatoid arthritis.