RA study populations from six Northwestern European countries included in the present study*
Total cases | Total controls | Sweden | Denmark | Iceland | Norway | UK biobank | FinnGen | |||||||
Ca | Co | Ca | Co | Ca | Co | Ca | Co | Ca | Co | Ca | Co | |||
RA overall | 31 313 | 995 377 | 8658 | 9418 | 7662 | 86 964 | 3613 | 341 788 | 881 | 28 517 | 5798 | 402 767 | 4701 | 125 923 |
Seropositive RA | 18 019 | 991 604 | 6455 | 9423 | 4850 | 86 964 | 1746 | 313 704 | 587 | 28 517 | 913 | 407 652 | 3468 | 145 344 |
Seronegative RA | 8515 | 1 015 471 | 1852 | 9436 | 2652 | 86 966 | 1069 | 322 808 | 455 | 28 517 | 1051 | 407 514 | 1436 | 143 312 |
Serology lacking | 4779 | – | 351 | – | 160 | – | 798 | – | 0 | – | 3834 | – | 0 | – |
*The following ICD-10 codes were used, in addition to clinical diagnoses validated by physicians, from case–control studies on RA or Scandinavian rheumatology quality and patient registers: RA overall (M05.8, M05.9, M06.0, M06.8, M06.9), seropositive RA (M05.8, M05.9 and/or positive rheumatoid factor (RF) and/or anti-CCP antibody measurement), seronegative RA (M06.0, M06.8 or M06.9 with negative RF measurement (and negative anti-CCP measurement if available). See Methods for further details.
Ca, number of cases; Co, number of controls; RA, rheumatoid arthritis.