Humoral and cellular immune responses before and after revaccination
| All | Non-RTX | RTX | ||||||
| N=66 | N=33 | N=33 | ||||||
| Before | After | P value* | Before | After | Before | After | P value† | |
| Seroconversion (anti-Spike S1 IgG) | ||||||||
| Negative, N (%) | 66 (100) | 33 (50.8) | <0.0001 | 33 (100) | 6 (18.7) | 33 (100) | 27 (81.8) | <0.0001 |
| Positive, N (%) | 0 (0) | 32 (49.2) | 0 (0) | 26 (78.8) | 0 (0) | 6 (18.2) | ||
| Missing, N | 0 | 1 | 0 | 1 | 0 | 0 | ||
| Neutralising capacity | ||||||||
| Negative, N (%) | 50 (89.3) | 31 (50.0) | <0.0001 | 24 (80.0) | 6 (20.0) | 26 (100) | 25 (78.1) | <0.0001 |
| Positive, N (%) | 6 (10.7) | 31 (50.0) | 6 (20.0) | 24 (80.0) | 0 (0) | 7 (21.9) | ||
| Missing, N | 10 | 4 | 3 | 3 | 7 | 1 | ||
| Anti-spike S1 IFN-gamma | ||||||||
| Negative, N (%) | 22 (40.7) | 16 (26.7) | 0.08 | 12 (54.5) | 12 (40.0) | 10 (31.2) | 4 (13.3) | 0.039 |
| Positive, N (%) | 32 (59.3) | 44 (73.3) | 10 (45.5) | 18 (60.0) | 22 (68.8) | 26 (86.7) | ||
| Missing, N | 12 | 6 | 11 | 3 | 1 | 3 | ||
The number of patients with non-missing data constitute the denominator in all cross-tabulations.
*McNemar test for paired categorical data before and after third vaccination.
†Fisher exact test comparing proportions after third vaccination.
IFN, interferon ; RTX, rituximab.