Table 1.

Baseline (time of RA diagnosis) characteristics

All patientsMulti-switching definition
A: ≥3 b/tsDMARDsB: ≥4 b/tsDMARDsC: ≥5 b/tsDMARDs
N, %23 908 (100)1677 (7)755 (3.2)385 (1.6)
Age (years), mean (SD)59.5 (15.2)50.3 (14.5)50.0 (14.6)47.6 (14.7)
Sex (male) %30.7%22.5%22.4%21.6%
CRP, mg/L (median, IQR)8.9 (4-22)10 (4-24)10 (4.2-25)10 (4-29)
ESR (median, IQR)23 (12-40)23 (25-39)23 (11-37.5)22 (11.8-36.3)
Patient global, VAS 0-100 (mean, SD)48.8 (26.8)58.4 (25.3)59.8 (24.5)60.8 (24.0)
Patient pain, VAS 0-100 (mean, SD)50.2 (26.8)59.2 (25.4)59.8 (25.2)59.9 (25.2)
Fatigue, VAS 0-100 (mean, SD)48.5 (28.8)61.2 (26.5)63.1 (25.9)64.6 (23.6)
HAQ (mean, SD)0.97 (0.66)1.1 3(0.64)1.15 (0.64)1.13 (0.63)
Swollen joint count (median, IQR)5 (2-9)6 (3-10)6 (3-10)6 (3-10)
Tender joint count (median, IQR)5 (2-9)6 (3-12)6 (3-12)7 (3-11.25)
Concomitant csDMARD, %52.5%50.4%51.7%51.4%
Reumatoid factor positive, %63.1%69.6%69.8%67.8%
ACPA positive, %67.0%73.4%74.3%72.7%
DAS28-ESR (mean, SD)4.62 (1.51)5.00 (1.41)5.10 (1.37)5.12 (1.33)
VAS general health physician (mean, SD)42.28 (23.02)45.30 (22.19)45.68 (20.69)51.40 (25.83)