Baseline variables associated with GP1111 withdrawal (RA shown below, similar findings for PsA and AxSpA)
| Univariate | Age- and gender adjusted | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95%CI) | p-value | |
| RA | ||||||
| Female gender | 0.9 (0.6-1.3) | 0.4 | - | 0.7 (0.5-1.2) | 0.2 | |
| Age, years | 1.0 (0.9-1.0) | 0.9 | - | 1.0 (0.9-1.1) | 0.6 | |
| Originator-experienced versus originator naïve to infliximab | 0.5 (0.3-0.8) | 0.002 | 0.5 (0.3-0.8) | 0.002 | 0.4 (0.2-0.9) | 0.01 |
| Methotrexate use, yes | 0.5 (0.3-0.7) | <0.001 | 0.5 (0.3-0.7) | <0.001 | 0.6 (0.4-0.9) | 0.01 |
| Comorbidities ≥1 | 1.1 (0.7-1.5) | 0.8 | 1.1 (0.7-1.5) | 0.8 | 0.9 (0.6-1.4) | 0.7 |
| In remission (yes) | 0.4 (0.3-0.6) | <0.001 | 0.4 (0.2-0.6) | <0.001 | 0.5 (0.3-0.7) | <0.001 |
| DAS28 | 1.7 (1.4-1.9) | <0.001 | 1.7 (1.5-1.9) | <0.001 | - | - |
| Patient global VAS, mm | 1.0 (1.0-1.1) | <0.001 | 1.0 (1.0-1.1) | <0.001 | - | - |